N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE (NT-proBNP) IN STAGE 1 AND STAGE 2 HYPERTENSION PATIENTS

  • Supriati Wila Djami Department of Health Analyst, Poltekkes Kemenkes Kupang, Kupang, Indonesia
Keywords: NT-proBNP, hypertension, degree of hypertension, duration of hypertension

Abstract

The increased levels of NT-proBNP in the blood occur when heart function, especially the left ventricular muscle chambers of the heart increases. Therefore, NT-proBNP is used as a biomarker to detect heart failure.The level of N Terminal – Pro Brain Natriuetic Peptide was independently associated with an increased risk of hypertension. This study aimed to determine the difference of NT-proBNP serum levels and the correlation between the levels of NT-proBNP in patients with stage 1 and stage 2 hypertension. This research was conducted at RSUP dr. Wahidin Sudirohusodo in August - September 2018. The study used a cross-sectional design with the total of 72 hypertensive patients, who had met the inclusive criteria. NT-proBNP levels were measured using the ELISA (Enzyme Linked Immunosorbent Assay) method.  The collected data was processed using Mann Whitney Different Test and Spearman's rho Correlation Test. The study results indicated that the level of NT-proBNP in the hypertensive patients with stage 2 was higher and significantly different (p = <0.001) compared to stage 1 hypertensive patients. NT-proBNP levels were higher in the hypertensive group of >6 years than in the hypertensive group <6 years. There were significant differences between the two groups statistically (p=0.010). It can be Conclude that there is a significant difference in the levels of NT-proBNP with a degree of hypertension where NT-proBNP levels were higher in patients with stage 2 hypertension compared to stage 1 hypertension, although  there was not statistically significant correlation between levels of NT-proBNP with Hypertension degree. Further research was needed to determine the relationship of NT-proBNP levels with the degree of hypertension, which can confirm the diagnosis, especially in patients with hypertension. Also, it is suggested to consider the accuracy of the data length of a patient suffering from undiagnosed hypertension.

Downloads

Download data is not yet available.

References

Rilantono, LI (2016). Cardiovascular disease. Jakarta: Faculty of Medicine, University of Indonesia.

Cardiovascular Specialist Doctors Association of Indonesia (CSDAI). (2015). Hypertension Management Guidelines on Cardiovascular Disease. Issue I. Jakarta: Cardiovascular Specialist Doctors Association of Indonesia.

Joint National Committee (JNC) 8. 2015. The Eighth Joint National Committee, Hypertension: The Silent Killer: Update JNC-8 Guideline.

Muhadi. (2016). JNC 8: Evidence-based Guideline. Handling Hypertension Adult Patients, (Online), Vol. 43, 1, (www.cdkjournal.com/index.php/CDK/article/, Accessed January 14, 2018).

South Sulawesi Provincial Health Office. 2015. Health Profile of South Sulawesi Province in 2015. Makassar: South Sulawesi Provincial Health Office.

Makassar City Health Office. 2015. 2015 Makassar City Health Profile Makassar: Makassar City Health Office.

Hulaima, I.S. 2017. Factors Associated with Control of Blood Pressure in Hypertensive Patients at the Kedaton City Bandar Lampung Health Center. Bandar Lampung: Faculty of Medicine, University of Lampung.

Hikmah, N. 2017. Relationship between Smoking Time and Hypertension in Rannaloe Village, Bungaya District, Gowa Regency. Makassar: Faculty of Medicine and Health UIN ALAUDDIN.

Karmelia T., Waspadji S., Ma'mun LH, S. Effendi, Ramli, M. & Timan IS (2017). Concentration Changes of Amino Terminal Pro B-Type natriuretic peptide (NT-proBNP) and Left Ventricular Ejection Fraction in Patients with Chemotherapy Doksorubisin.Jurnal disease in Indonesia. 4 (2): 78-82.

Jambia, A., Putri, F.A., Fitriani, N.N., Primasari, N., Shobri, S.Z., Azizah, S. & Sumars, W.O. 2017. Kendari Department of Health Analyst: Hypertension Paper (Clinical Chemistry). Infectious Disease "Hypertension", (Online), (http://amsarjambia.blogspot.co.id/, accessed 02 January 2018).

Stefannus, M. (2015) Positive .Hubungan Between Degree of Liver Diseases Cirrhosis with N terminal - pro brain natriuretic peptide (NT-proBNP) in liver cirrhosis. Denpasar: Master of Biomedical Sciences Program Udayana University.

Khairunnisa. (2017). Correlation Levels of NT - proBNP with Left Ventricular Ejection Fraction Function in Children Heart Failure. Padang: Graduate Program in Biomedical Sciences - Medical Specialist Education Program UNAND - RS.M.DJAMIL.

Bower et al., (2015) .N-terminal pro-brain natriuretic peptide (NT-proBNP) and Risk of Hypertension in the Atherosclerosis Risk in Communities (ARIC) Study.American Journal of Hypertension. 28 (10): 1262-1266.

Azhar, I. (2017). Hypertension Patient Characteristics picture in Sleman Gamping Puskesmas Yogyakarta.Yogyakarta: College of Health Sciences of the University General Achmad Yani Yogyakarta.

Sarzani, R. et al (2016). NT-proBNP and Its Correlation Hospital Mortality in the Very Elderly without and Admission Diagnosis of Heart Failue.PLOS Journals.Vol 10 No. 1371.

Published
2019-10-18
How to Cite
Djami, S. W. (2019). N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE (NT-proBNP) IN STAGE 1 AND STAGE 2 HYPERTENSION PATIENTS. Indonesian Journal of Medical Laboratory Science and Technology, 1(2), 65-67. https://doi.org/10.33086/ijmlst.v1i2.1159