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Hafidz Hanafi https://orcid.org/0009-0005-3040-4385
Besut Daryanto https://orcid.org/0000-0002-0776-1633
Atma Gunawan https://orcid.org/0000-0003-3661-5894

Abstract

Chronic Kidney Disease (CKD) is a condition of gradual or chronic decline in kidney function, which is quite severe and caused by various kidney diseases, including urinary obstruction. This disease is progressive and generally irreversible. CKD requires kidney replacement therapy, one of which is continuous ambulatory peritoneal dialysis (CAPD). To determine the prevalence and risk factors for End Stage Renal Disease (ESRD) in patients undergoing CAPD due to urinary obstruction. We performed a retrospective cohort with a cross-sectional study was conducted using secondary data from medical record data of ESRD patients with CAPD accompanied by urinary obstruction at Dr. Saiful Anwar General Hospital, Malang, Indonesia. The prevalence of CKD in patients with CAPD accompanied by urinary obstruction was 6,50% and dominated by males (57,8%) with an age range of 41-50 years (26%). The majority of comorbidities are severely high the Body Mass Index (BMI) (89,0%) and hypertension (80,8%). The location of obstruction is mostly unilateral (5,64%) with mild levels (4,06%). Urinary obstruction is a frequent clinical finding in CKD patients with CAPD. The most common risk factor in this study was hypertension. The prevalence and comorbidities among CAPD patients with Urinary obstruction (UO) are better understood because to this study. It is necessary to recognise its limitations, particularly the small sample size and single-centre design. Future studies should involve more centres and larger patient groups in order to provide a more thorough knowledge of the mechanisms behind the high survival rates among CAPD patients.

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How to Cite
Hanafi, H., Daryanto, B. and Gunawan, A. (2024) “Prevalence and comorbid for late-stage chronic kidney disease (CKD) in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) due to urinary obstruction”, Indonesian Journal of Medical Laboratory Science and Technology, 6(2), pp. 143–150. doi: 10.33086/ijmlst.v6i2.5821.
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Blumea balsamifera , Sargassum aquifolium , Fatty liver disease, Hypercholesterolemia, Lipid metabolism

References

Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64(1):73–84. https://doi.org/10.1002/hep.28431

Singh I, Strandhoy J, Assimos D. Campbell-walsh urology tenth edition, 2012, p. 1087–121. https://shop.elsevier.com/books/campbell-walsh-urology-10th-edition-review/mcdougal/978-1-4377-2393-9

KDIGO. Official Journal of the international Society of Nephrology KDIGO 2012: Clinical practice guideline for the evaluation and management of chronic kidney disease. 2013. https://doi.org/10.1038/kisup.2012.64

Kazancioğlu R. Risk factors for chronic kidney disease: an update. Kidney Int Suppl (2011). 2013;3(4):368–71. https://doi.org/10.1038/kisup.2013.79

PERNEFRI. Report of Indonesian renal registry 2020. 2020. https://www.indonesianrenalregistry.org/data/IRR%202020.pdf

Zeidel ML. Obstructive Uropathy. Goldman’s cecil medicine, Elsevier; 2012, p. 776–80. https://doi.org/10.1016/B978-1-4377-1604-7.00125-1

Girardi M, Martin N. Obstructive uropathy. Hospital Medicine Clinics. 2015.4(3):328–341. https://doi.org/10.1016/j.ehmc.2015.03.010

Yu ASL, Chertow GM, Luyckx V, Marsden PA, Shorecki K, Taal MW.Brenner and rector’s the kidney e-book. Elsevier Health Sciences. 2015. https://books.google.co.id/books?id=NX7OCgAAQBAJ

Kirsten KM. Pathophysiology of urinary tract obstruction campbell’s urology 2016 11th ed. Philadelphia: W.B. Saunders Company; 2016. https://shop.elsevier.com/books/campbell-walsh-urology/wein/978-1-4557-7567-5

Ucero AC, Gonçalves S, Benito-Martin A. Obstructive renal injury: from fluid mechanics to molecular cell biology. Res Rep Urol. 2010;2:41–55. https://doi.org/10.2147/RRU.S6597

Parsudi I, Siregar P, Roesli R. Dialisis peritoneal. In: Textbook of internal medicine (4th Edition). Jakarta: Interna Publishing. 2017. https://onesearch.id/Record/IOS5392.ai:slims-19881

Sjamsuhidajat, R. Textbook of surgery (2nd Edition). [Buku ajar ilmu bedah (Ed 2)]. Jakarta: EGC. 2004.

Munib S. Continuous Ambulatory Peritoneal Dialysis (CAPD). Gomal Journal of Medical Sciences. 2006;4(2):82-85. https://gjms.com.pk/index.php/journal/article/view/95/93

Indonesian Ministry of Health. RISKESDAS Main Results 2018. 2018. https://repository.badankebijakan.kemkes.go.id/id/eprint/3514/

Gambaro G, Croppi E, Bushinsky D, Jaeger P, Cupisti A, Ticinesi A, et al. The risk of chronic kidney disease associated with urolithiasis and its urological treatments: A review. J Urol. 2017;198(2):268–73. https://doi.org/10.1016/j.juro.2016.12.135

Erfanpoor S, Etemad K, Kazempour S, Hadaegh F, Hasani J, Azizi F, Parizadeh D, Khalili D. Diabetes, hypertension, and incidence of chronic kidney disease: Is there any multiplicative or additive interaction? Int J Endocrinol Metab. 2020;19(1). https://doi.org/10.5812/ijem.101061

Yang J, Sun BG, Min H-J, Son Y-B, Kim T B, Lee J, et al. Impact of acute kidney injury on long-term adverse outcomes in obstructive uropathy. Scientific Reports. 2021;11(1): 23639. https://doi.org/10.1038/s41598-021-03033-0

Sherer BA, Stoller ML. Obstructive uropathy. Nephrology Secrets, Elsevier; 2019:110–2. https://doi.org/10.1016/B978-0-323-47871-7.00025-3

Centers for Disease Control and Prevention. Chronic Kidney Disease Surveillance System—United States. website. http://www.cdc.gov/ckd

Hsu CW, Yamamoto KT, Henry RK, De Roos AJ, Flynn JT. Prenatal risk factors for childhood CKD. Journal of the American Society of Nephrology. 2014;25:2105–11. https://doi.org/10.1681/ASN.2013060582

Gunawan A, Sakti PT. Five-year survival rate of patients with end-stage renal disease on Continuous Ambulatory Peritoneal Dialysis (CAPD) at Malang CAPD Center, Indonesia. Acta Med Indones. 2023 Jan;55(1):4-9. https://www.actamedindones.org/index.php/ijim/article/view/2117

Neugarten J, Golestaneh L. Influence of sex on the progression of chronic kidney disease. Mayo Clinic Proceedings. 2019;94(7):1339–56 https://doi.org/10.1016/j.mayocp.2018.12.024

Prasad R, Jha RK, Keerti A. Chronic kidney disease: Its relationship with obesity. Cureus. 2022;14(10):e30535. https://doi.org/10.7759/cureus.30535

Garofalo C, Borrelli S, Minutolo R, Chiodini P, De Nicola L, Conte G. A systematic review and meta-analysis suggests obesity predicts onset of chronic kidney disease in the general population. Kidney Int. 2017;91(5):1224–35. https://doi.org/10.1016/j.kint.2016.12.013

Assadi F. The growing epidemic of chronic kidney disease: Preventive strategies to delay the risk for progression to ESRD. Adv Exp Med Biol 2019;1121:57–9. https://doi.org/10.1007/978-3-030-10616-4_6

Wang Y, Chen X, Song Y, Caballero B, Cheskin LJ. Association between obesity and kidney disease: a systematic review and meta-analysis. Kidney Int. 2008;73(1):19–33. https://doi.org/10.1038/sj.ki.5002586

Laddha AP, Kulkarni YA. Correction: Daidzein attenuates urinary bladder dysfunction in streptozotocin-induced diabetes in rats by NOX-4 and RAC-1 inhibition. Naunyn Schmiedebergs Arch Pharmacol. 2023;396(8):3895–6. https://doi.org/10.1007/s00210-023-02777-y

Matsuo T, Miyata Y, Araki K, Mukae Y, Otsubo A, Ohba K, et al. Efficacy of tadalafil therapy and changes in oxidative stress levels in male patients with lower urinary tract symptoms and overactive bladder. LUTS: Lower Urinary Tract Symptoms 2020;12(1):47–53. https://doi.org/10.1111/luts.12283

Erdogan BR, Liu G, Arioglu-Inan E, Michel MC. Established and emerging treatments for diabetes-associated lower urinary tract dysfunction. Naunyn Schmiedebergs Arch Pharmacol 2022;395(8):887–906. https://doi.org/10.1007/s00210-022-02249-9

Michel MC, Chess-Williams R, Hegde SS. Are blood vessels a target to treat lower urinary tract dysfunction? Naunyn Schmiedebergs Arch Pharmacol. 2015;388(7):687–94. https://doi.org/10.1007/s00210-015-1137-y

Cho ST, Park EY, Kim JC. Effect of angiotensin II receptor antagonist telmisartan on detrusor overactivity in rats with bladder outlet obstruction. Urology. 2012;80(5):1163.e1-7. https://doi.org/10.1016/j.urology.2012.05.002

Siddiqui MM, McDougal WS. Urologic assessment of decreasing renal function. Med Clin North Am. 2011;95(1):161–8. https://doi.org/10.1016/j.mcna.2010.08.031

Mourmouris. Obstructive uropathy: from etiopathology to therapy. World J Nephrol Urol. 2014;3(1):1-6. https://doi.org/10.14740/wjnu154w

Klomjit N, Kattah AG, Cheungpasitporn W. The cost-effectiveness of peritoneal dialysis is superior to hemodialysis: updated evidence from a more precise model. Kidney Med. 2021;3(1):15–7. https://doi.org/10.1016/j.xkme.2020.12.003

Hafidz Hanafi, Universitas Brawijaya

Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia

Besut Daryanto, Universitas Brawijaya

Department of Urology, Faculty of Medicine Universitas Brawijaya, Malang, Indonesia

Atma Gunawan, Universitas Brawijaya

Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia