Assessment of Platelet Indices Profile of Pregnant Women Attending University of Abuja Teaching Hospital, Nigeria

Abstract

Platelets initiate hemostasis by aggregating at the site of injury and participate in ensuring endothelial integrity. A defect in this process could lead to intravascular blood loss. This case-control study sought to determine the platelet counts and indices among pregnant women in the University of Abuja Teaching Hospital Gwagwalada, Abuja, Nigeria. A total of 120 pregnant women as case and 60 non-pregnant women as control were enrolled for this study. Blood samples were collected in EDTA tubes, and complete platelet count and indices were carried out using an automated five-part haematology analyzer. The mean ± standard deviation of the platelets count among the pregnant women, 226.54 ± 69.76 10⁹ cells/L was not significantly different from that of the non-pregnant women, 214.95 ± 52.22x 10⁹ cells/L (p=0.295). There was a significant differences in mean platelets volume (MPV) of the case and control groups (p=0.036). After post-hoc test, the significant difference was between the  pregnant women in 3^rd trimester and the control group (p=0.014). However, there was no diffences in the mena platelets larger cell ratio and platelet distribution width in the case and control groups. Fifteen (11.0%) and 7 (12.1%) of the case and control control groups, respectively had mild thrombocytopenia. However, there was no significant association between pregnant status and thrombocytopenia (p=0.836). Based on these findngs, it can be infered that platelet count and MPV decreases while PDW increase with the progression of gestation age compared to the non-pregnant women.