Correlation of Side Effects of ARV (Antiretroviral) Drugs with ARV Therapy Compliance in PLWHA at KDS Jombang Care Center Plus of Jombang Regency
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Riska Putri Dessyanti
Wira Daramatasia
Yuliyanik Yuliyanik
Abstract
Human Immunodeficiency Virus (HIV) attacks white blood cells, leading to a weakened
immune system. Acquired Immune Deficiency Syndrome (AIDS) refers to the set of
symptoms caused by the decline in immunity due to HIV. Antiretroviral therapy (ART)
is used to suppress viral replication, with treatment success largely dependent on
adherence to therapy. However, side effects of antiretroviral drugs can negatively
impact adherence by causing unwanted symptoms that discourage patients from
continuing treatment. This study aims to analyze the correlation between the side effects
of antiretroviral drugs and adherence to antiretroviral therapy among people with
HIV/AIDS in the Jombang Care Center Plus Peer Support Community, Jombang
Regency. This study used a cross-sectional design with purposive sampling, involving
38 respondents. Adherence to ART was assessed using the Morisky Medication
Adherence Scale-8 (MMAS-8) questionnaire, while the side effects of antiretroviral
drugs were evaluated using the Group Clinical Trial AIDS questionnaire. Statistical
analysis was performed using Somers' D test. The Somers' D test showed a significant
correlation between the side effects of antiretroviral drugs and adherence to therapy (p =
0.002, p < 0.05). This study concludes that side effects of antiretroviral drugs are
significantly associated with adherence to antiretroviral therapy among people with
HIV/AIDS in the Jombang Care Center Plus Peer Support Community.
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References
Achappa, B. et al. (2013) ‘Adherence to antiretroviral therapy among people living with HIV’, North
American Journal of Medical Sciences, 5(3), pp. 220–223. doi: 10.4103/1947-2714.109196. DOI: https://doi.org/10.4103/1947-2714.109196
Bagus Arisudhana, G. A., Sofro, M. A. U. and Sujianto, U. (2019) ‘Antiretroviral Side Effect on
Adherence in People Living With Hiv Aids At Dr. Kariadi General Refferal Hospital
Semarang Central Java’, Nurse Media Journal of Nursing, 8(2), p. 79. doi:
14710/nmjn.v8i2.20742.
Centers for Disease Control and Prevention. (2021). HIV Treatment.
https://www.cdc.gov/hiv/basics/livingwithhiv/treatment.html Corbett, A. H., & Dana, J. W.
(2016). Drug information Handbook (25th Editioned.). America:American Pharmacy
Association
Dinkes Jatim. 2021. Profil Kesehatan Jawa Timur 2021. Surabaya: Dinas Kesehatan Provinsi Jawa
Timur.Dinkes Kabupaten Jombang. 2021. Profil Kesehatan Kabupaten Jombang. Jombang: Dinas Kesehatan
Kabupaten Jombang
Djumadi, J. and Gobel, F. A. (2023) ‘Faktor yang Berhubungan dengan Kepatuhan Terapi
Antiretroviral ( ARV ) pada Pengidap HIV / AIDS di Rumah Sakit Bhayangkara Kota
Makassar Tahun 2022’, 4(1), pp. 78–90. DOI: https://doi.org/10.47354/jiihif.v1i1.443
Fatimatuzahro., Bagoes, Widjanarko., & Zahroh, S. (2023) ‘Model Pengembangan Aplikasi “Ingat
Minum Obat ARV” Berbasis Android Sebagai Pengingat Minum Obat Pada ODHA’, Jurnal
Keperawatan Silampari, 6(2), pp. 1479–1491.
Hadisaputro, S. and Sofro, M. A. U. (2020) ‘Side Effects Factors Affect the Compliance of
Antiretroviral Treatment in Plwhs : Study of Undata District General Hospital , Palu’, 19(1),
pp. 16–24.
Holly, Swan., Joel, I Roisman., Sarah, Mcdonald., Mark, E Glickman., Keith, D Mchnnes .,& Allen,
L. G. (2018) ‘The Relayionship Between Gastrointestinal Symptom
Attribution,Bothersomeness,and Antiretroviral Adherence Among Adults with HIV’,
Department of Health and Human Services USA, 30(8), pp. 997–1003. doi:
1080/09540121.2018.1437254.The.
Kemenkes RI. (2020). Laporan Situasi Perkembangan HIV AIDS dan PIMS di Indonesia, Triwulan
III Tahun 2019. Jakarta
Kemenkes RI. (2022). Profil Kesehatan Indonesia. Jakarta: Kementerian Kesehatan Republik
Indonesia
Mackenzie, Cottrel., Tanja, Hadzic.,&Angela, K. (2014) ‘Clinical
Pharmacokinetic,Pharmacodynamic , and Drug Interaction Profile of the Integrase Inhibitor
Dolutegravir’, National Institutes of Health, 52(11), pp. 981–994. doi: 10.1007/s40262-013-
-2.Clinical.
Nurarif, A. H., & Kusuma, H. (2015). Aplikasi asuhan keperawatan berdasarkandiagnosis medis dan
Nanda nic noc. Yogyakarta: Mediaction
Nursalam. (2018). Metodologi penelitian ilmu keperawatan. Jakarta: Salemba Medika
Puspasari, D., Wisaksana, R. and Ruslami, R. (2018) ‘Gambaran Efek Samping dan Kepatuhan
Terapi Antiretroviral pada Pasien HIV di Rumah Sakit Dr . Hasan Sadikin Bandung Tahun
in HIV Patients at Dr . Hasan Sadikin Hospital in 2015’, Jsk, 3(4), pp. 175–181.
Sitorus, R. J., Syakurah, R. A. and Natalia, M. (2021) ‘Efek Samping Terapi Antiretroviral dan
Kepatuhan Berobat Penderita HIV / AIDS Side Effects of Antiretroviral Therapy and
Medication Adherence among HIV / AIDS Patients’, 12, pp. 389–395.
UNAIDS. (2021). UNAIDS Data 2021. Geneva: Joint United Nations Programme on HIV/AIDS.
WHO.(2021). Global HIV Programme-Key Facts HIV. World Health Organization.
