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Alfi Syahri Tintin Sukartini Sukartini Erna Dwi Wahyuni Sriyono Sriyono Hakim Zulkarnain Wikan Purwihantoro Sudarmaji Domingos Soares Mawaddah Fitria Eti Rahmawati

Abstract

Introduction: HIV/AIDS remains a global public health challenge, with opportunistic infections (OIs) being a major cause of morbidity and mortality. In resource-limited settings such as Aceh, Indonesia, the burden of OIs significantly impacts the management and outcomes of HIV/AIDS patients. Purpose: This study aims to describe the demographic and clinical characteristics, the prevalence of OIs, and treatment outcomes among HIV/AIDS patients treated at Cut Mutia General Hospital in Lhokseumawe, Aceh. Methods: A retrospective observational study was conducted using medical records of 55 HIV/AIDS patients treated between January 2023 and October 2024. Data included demographic profiles, clinical features, types of OIs, and treatment outcomes. Descriptive statistical analysis was performed. Results: The majority of patients were male (67.3%) and aged 25–44 years (81.8%). Oral candidiasis (28.1%) and pulmonary tuberculosis (17.7%) were the most common OIs. Notably, some patients experienced multiple OIs. Most patients (76.4%) were discharged in stable condition, while 23.6% succumbed to their illnesses. Conclusions: This study highlights the high prevalence of OIs among HIV/AIDS patients in Lhokseumawe, emphasizing the need for early detection, improved clinical management, and integrated care services. Targeted interventions are critical to reducing mortality and improving patient outcomes in resource-constrained settings.

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Syahri, A., Sukartini, T. S., Wahyuni, E. D., Sriyono, S., Zulkarnain, H., Sudarmaji, W. P. ., Soares, D. ., Fitria, M., & Rahmawati, E. . (2025). Study of Clinical Characteristics of AIDS Patients With Opportunistic Infections: Findings From Cut Mutia General Hospital . Journal of Health Sciences, 18(01), 105–114. https://doi.org/10.33086/jhs.v18i01.6970
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Articles
HIV, AIDS, opportunistic infections

References

Adamu, H., & Petros, B. (2010). Intestinal Protozoan Infections Among HIV Positive Persons With and Without Antiretroviral Treatment (ART) in Selected ART Centers in Adama, Afar and Dire-Dawa, Ethiopia. Ethiopian Journal of Health Development, 23(2). https://doi.org/10.4314/ejhd.v23i2.53230

Ahmetagic, S., Porobic-Jahic, H., Piljic, D., Custovic, A., Sabitović, D., & Zepic, D. (2015). Clinical and Epidemiological Characteristics of HIV Infection/Aids in Hospitalized Patients. Materia Socio Medica, 27(1), 27. https://doi.org/10.5455/msm.2014.27.27-30

Almaw, A. (2024). Prevalence of Opportunistic Intestinal Coccidian Parasites and Associated Factors in HIV/AIDS Patients Attending Anti‐retroviral Therapy (ART) Clinic at Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia: A Cross‐sectional Study. Health Science Reports, 7(9). https://doi.org/10.1002/hsr2.70056

Ando, K. (2024). Impact of HIV Status on Prognosis of Malignancies Among People Living With HIV in Japan. Cancer. https://doi.org/10.1002/cncr.35351

Buchacz, K., Lau, B., Jing, Y., Bosch, R. J., Abraham, A. G., Gill, M. J., Silverberg, M. J., Goedert, J. J., Sterling, T. R., Althoff, K. N., Martin, J. N., Burkholder, G. A., Gandhi, N. R., Samji, H., Patel, P., Rachlis, A., Thorne, J. E., Napravnik, S., Henry, K., … Brooks, J. T. (2016). Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000–2010. The Journal of Infectious Diseases, 214(6), 862–872. https://doi.org/10.1093/infdis/jiw085

Damtie, D., Yismaw, G., Woldeyohannes, D., & Anagaw, B. (2013). Common Opportunistic Infections and Their CD4 Cell Correlates Among HIV-infected Patients Attending at Antiretroviral Therapy Clinic of Gondar University Hospital, Northwest Ethiopia. BMC Research Notes, 6(1). https://doi.org/10.1186/1756-0500-6-534

Dawet, A., & Onaiyekan, O. E. (2020). Prevalence of Malaria and Some Opportunistic Infections in Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) Patients With CD4 Below 200 in Faith Alive Hospital, Jos, Plateau State, Nigeria. International Journal of Virology and Aids, 7(1). https://doi.org/10.23937/2469-567x/1510058

Dereje, N., Moges, K., Nigatu, Y., & Holland, R. (2019). Prevalence And Predictors Of Opportunistic Infections Among HIV Positive Adults On Antiretroviral Therapy (On-ART) Versus Pre-ART In Addis Ababa, Ethiopia: A Comparative Cross-Sectional Study. HIV/AIDS - Research and Palliative Care, Volume 11, 229–237. https://doi.org/10.2147/HIV.S218213

Elango, K., Mudgal, M., Murthi, S., Yella, P. R., Nagrecha, S., Srinivasan, V., Sekar, V., Koshy, M., Ramalingam, S., & Gunasekaran, K. (2022). Trends in the Epidemiology and Outcomes of Pneumocystis Pneumonia Among Human Immunodeficiency Virus (HIV) Hospitalizations. International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph19052768

Epplein, M., Bostick, R. M., Mu, L., Ogino, S., Braithwaite, D., & Kanetsky, P. A. (2014). Challenges and Opportunities in International Molecular Cancer Prevention Research: An ASPO Molecular Epidemiology and the Environment and International Cancer Prevention Interest Groups Report. Cancer Epidemiology, Biomarkers & Prevention, 23(11), 2613–2617. https://doi.org/10.1158/1055-9965.EPI-14-0848

Fatimatuzzahra, D. S. L., Ganiem, A. R., Cahyani, A., Gunadharma, S., & Dian, S. (2022). Prevalence of Opportunistic Infection in Central Nervous System Among Patients With HIV/AIDS at Dr. Hasan Sadikin General Hospital Bandung, Indonesia. Althea Medical Journal, 9(2), 100–105. https://doi.org/10.15850/amj.v9n2.2298

Fenner, L., Atkinson, A., Boulle, A., Fox, M. P., Prozesky, H., Zürcher, K., Ballif, M., Furrer, H., Zwahlen, M., Davies, M., & Egger, M. (2017). HIV Viral Load as an Independent Risk Factor for Tuberculosis in South Africa: Collaborative Analysis of Cohort Studies. Journal of the International Aids Society, 20(1). https://doi.org/10.7448/ias.20.1.21327

Harjoni. (2023). Pemberian Mitigasi Dan Pemberdayaan ODHA Di Aceh Melalui Kelompok Dukungan Sebaya (KDS) Seudara. Sambara Jurnal Pengabdian Kepada Masyarakat, 1(2), 83–89. https://doi.org/10.58540/sambarapkm.v1i2.256

Kawakami, M., Tominaga, M., Yano, C., Okamoto, M., Nakamura, M., Sakazaki, Y., Naito, Y., Kawayama, T., & Hoshino, T. (2018). Correlation of CT Findings and Clinical Characteristics of Pneumocystis Pneumonia in Patients With Acquired Immunodeficiency Syndrome. Biology and Medicine. https://doi.org/10.4172/0974-8369.1000447

Mo, I. (2016). Disparities in the Magnitude of Human Immunodeficiency Virus-Related Opportunistic Infections Between High and Low/Middle-Income Countries: Is Highly Active Antiretroviral Therapy Changing the Trend? Annals of Medical and Health Sciences Research, 6(1), 4. https://doi.org/10.4103/2141-9248.180234

Montúfar-Andrade, F. E., Villa-Franco, J. P., Montúfar-Pantoja, M. C., Cadavid-Usuga, J. C., Monsalve, M. A., Zuluaga, M., Díaz, L., Vega, J., Vélez, J. D., Zuleta-Tobón, J. J., Zuleta-Tobón, J. J., & Madrid, C. (2016). Pulmonary compromise in inpatients with human immunodeficiency virus infection at Pablo Tobón Uribe Hospital, Medellín, Colombia | Compromiso pulmonar en pacientes hospitalizados con infección por el virus de inmunodeficiencia humana en el Hospital Pablo . Infectio, 20(4), 211–217. https://doi.org/10.1016/j.infect.2015.10.004

Opoku, Y. K., Boampong, J. N., Ayi, I., Kwakye-Nuako, G., Obiri‐Yeboah, D., Koranteng, H., Ghartey‐Kwansah, G., & Asare, K. K. (2018). Socio-Behavioral Risk Factors Associated With Cryptosporidiosis in HIV/AIDS Patients Visiting the HIV Referral Clinic at Cape Coast Teaching Hospital, Ghana. The Open Aids Journal, 12(1), 106–116. https://doi.org/10.2174/1874613601812010106

Pantazis, N., Paparizos, V., Papastamopoulos, V., Metallidis, S., Antoniadou, A., Adamis, G., Psichgiou, M., Chini, M., Sambatakou, H., Chrysos, G., Sipsas, N. V, Gogos, C., Barbunakis, E., Panagopoulos, P., Κατσαρού, Ό., & Touloumi, G. (2023). Low Pre-Art CD4 Count Is Associated With Increased Risk of Clinical Progression or Death Even After Reaching 500 CD4 Cells/ΜL on ART. Plos One. https://doi.org/10.1371/journal.pone.0283648

Patel, C. (2023). An Unusual Discovery of Multi-Opportunistic Organisms in Gastrointestinal Biopsies of a Patient With Acquired Immunodeficiency Syndrome and Infectious Colitis. Cureus. https://doi.org/10.7759/cureus.50124

Pinheiro, M. V. C., Ho, Y.-L., Nicodemo, A. C., & Duarte-Neto, A. N. (2018). The Diagnosis of Multiple Opportunistic Infections in Advanced Stage AIDS: When Ockham S Razor Doesn T Cut It. Autopsy and Case Reports, 8(2). https://doi.org/10.4322/acr.2018.028

Qua, K., Papp, K. K., Junk, D. J., Webb Hooper, M., & Berger, N. A. (2020). Youth Enjoy Science Program at the Case Comprehensive Cancer Center: Increasing Engagement and Opportunity for Underrepresented Minority Students. Ethnicity & Disease, 30(1), 15–24. https://doi.org/10.18865/ed.30.1.15

Radisic, M. (2018). Extrapulmonary Pneumocystis Jirovecii Presenting as Fever and Lymphadenopathies. Case Report and Literature Review. Journal of Infectious Diseases & Travel Medicine. https://doi.org/10.23880/jidtm-16000113

Sanyaolu, A., Oyibo, W. A., Iriemenam, N. C., & Badaru, O. S. (2016). Sero-Prevalence Study of Parasitic Infections Among HIV Positive and Negative Patients in Lagos, Nigeria. African Journal of Clinical and Experimental Microbiology, 17(2), 88. https://doi.org/10.4314/ajcem.v17i2.3

Savadogo, M., Diallo, I., & Sondo, K. A. (2021). Opportunistic Infections Diagnosed in Patients Infected With the Human Immunodeficiency Virus (Hiv) at the Service of Infectious Diseases of Uhc (University Hospital Center) Yalgado Ouédraogo, Burkina Faso. Pijr, 1–2. https://doi.org/10.36106/paripex/7006220

Shi, Y., Lu, H., He, T., Yang, Y. L., Liu, L., Zhang, R., Zheng, Y., Shen, Y., Zhang, Y., & Zhang, Z. (2011). Prevalence and Clinical Management of Cytomegalovirus Retinitis in AIDS Patients in Shanghai, China. BMC Infectious Diseases, 11(1). https://doi.org/10.1186/1471-2334-11-326

Teeka, J. S. (2023). Factors Associated With Opportunistic Infections Among HIV/AIDS Patients Attending Comprehensive Care Clinic at Mbagathi District Hospital. https://doi.org/10.21203/rs.3.rs-3262226/v1

Tewachew, A. S., Negash, W., Mekuria, A. D., & Amare, Y. E. (2021). Determinants of Opportunistic Infections Among HIV-Positive Patients on HAART in Debre Berhan Referral Hospital, North Shoa Zone, Ethiopia, 2020: A Case–Control Study. Hiv/Aids - Research and Palliative Care. https://doi.org/10.2147/hiv.s298661

Utarini, G. A. E. (2017). Predictors of Improved Nutritional Status Among HIV/AIDS Patients Who Received Antiretroviral Therapy (ART) at Sanglah General Hospital Denpasar. Public Health and Preventive Medicine Archive, 5(2), 147–151. https://doi.org/10.53638/phpma.2017.v5.i2.p14

WHO. (2021). Key Facts HIV/AIDS. Www.Who.Int/News-Room/Fact-Sheets/Detail/Hiv-Aids.

Wulandari, A. (2023). Risk Factors and Adverse Drug Reactions in HIV/AIDS Patients at Undata Regional Hospital in Palu City, Indonesia. Sciences of Pharmacy, 2(4), 45–53. https://doi.org/10.58920/sciphar02040045

Alfi Syahri, Faculty of Nursing, Universitas Airlangga, Surabaya, Indonesia

Alfi Syahri, is a lecturer and specialist medical surgical nurse at the Department of Advanced Nursing, Faculty of Nursing, Deli Husada Health Institute and his research areas are Medical Surgical Nursing, Chronic Disease, Oncology, Cardiovascular, HIV & AIDS, palliative. Alfi Syahri is a lecturer who teaches basic nursing courses, medical surgical care, critical care, emergency care, and palliative care. Alfi is currently pursuing a doctoral degree at the Faculty of Nursing, Airlangga University, Surabaya.

Tintin Sukartini Sukartini, Faculty of Nursing, Universitas Airlangga, Surabaya, Indonesia

Erna Dwi Wahyuni, Faculty of Nursing, Universitas Airlangga, Surabaya, Indonesia

Sriyono Sriyono, Faculty of Nursing, Universitas Airlangga, Surabaya, Indonesia

Hakim Zulkarnain, Faculty of Nursing, Universitas Airlangga, Surabaya, Indonesia

Wikan Purwihantoro Sudarmaji, Faculty of Nursing, Universitas Airlangga, Surabaya, Indonesia

Domingos Soares, Instituto Nacional de Saúde Pública, Dili, Timor-Leste

Mawaddah Fitria, Cut Mutia General Hospital, Aceh, Indonesia

Eti Rahmawati, Cut Mutia General Hospital, Aceh, Indonesia