Vol. 7 No. 2 (2025) From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook

Biomedical research highlights the dual nature of natural compounds: promising therapeutic potential alongside necessary safety considerations. Studies demonstrate Bromelain and Mango seed extracts effectively combat antibiotic-resistant bacteria, while lemongrass-derived diethyl phthalate shows anti-SARS-CoV-2 activity. However, Ciplukan extract reveals organ toxicity at sublethal doses, underscoring the need for safety profiling. Concurrently, STAT3 emerges as a key independent driver in colorectal cancer progression, and environmental toxins like mosquito coil smoke are confirmed to cause emphysema. These findings collectively advocate for an integrated approach in therapeutic development, balancing efficacy with rigorous safety assessment across infectious diseases, oncology, and environmental health.

The articles in this issue were authored/co-authored by authors Malaysia and Indonesia

DOI: https://doi.org/10.33086/ijmlst.v7i2
Published: 2025-10-25

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Articles

In vivo effect of bromelain from Ananas comosus on Staphylococcus aureus skin infection in an animal model

MY Siti Nur Atikah Zul,  Universiti Kuala Lumpur,  Malaysia
MY Mohd Shazwan Shazdee Wahab,  Universiti Kuala Lumpur,  Malaysia
MY Elysha Nur Ismail,  Universiti Putra Malaysia,  Malaysia
MY Reezal Ishak,  Universiti Kuala Lumpur,  Malaysia
DOI : https://doi.org/10.33086/ijmlst.v7i2.5739
80-87
2025-10-25
Abstract views: 584 , Downloads : 470

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Potential of ethanolic extracts from seed kernel Indonesian cultivars mangoes as an anti-multidrug-resistant (MDR) Escherichia coli

ID Tulus Ariyadi,  Universitas Muhammadiyah Semarang,  Indonesia
ID Sitti Qayimah,  Universitas Muhammadiyah Semarang,  Indonesia
ID Lulu’ Nur Assa’diyah,  Universitas Muhammadiyah Semarang,  Indonesia
ID Asyiah Asyiah,  Universitas Muhammadiyah Semarang,  Indonesia
ID Hanum Adisty Pratiwi,  Universitas Muhammadiyah Semarang,  Indonesia
ID Afifah Khairunnisa,  Universitas Muhammadiyah Semarang,  Indonesia
ID Annisa Nurul Hikmah,  Universitas Muhammadiyah Semarang,  Indonesia
ID Lia Kusmita,  Stifar Yayasan Pharmasi Semarang,  Indonesia
ID Mutmainah Mutmainah,  Stifar Yayasan Pharmasi Semarang,  Indonesia
ID Ana Hidayati Mukaromah,  Universitas Muhammadiyah Semarang,  Indonesia
DOI : https://doi.org/10.33086/ijmlst.v7i2.5837
88-97
2025-10-25
Abstract views: 578 , Downloads : 377

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Effect of subacute toxicity of mosquito coil smoke inhalation on lung histology and blood hematology parameters in Wistar rats

ID Mulyati Sri Rahayu,  Universitas Malikussaleh,  Indonesia
ID Sri Wahyuni,  Universitas Malikussaleh,  Indonesia
DOI : https://doi.org/10.33086/ijmlst.v7i2.6046
98-107
2025-10-26
Abstract views: 672 , Downloads : 547

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Molecular identification and antibacterial activity of endophytic bacteria from Bambusa vulgaris leaves as antibacterial potential against phatogenic microoganism

ID Jekmal Malau,  Universitas Singaperbangsa Karawang,  Indonesia
ID Vriezka Mierza,  Universitas Singaperbangsa Karawang,  Indonesia
ID Munir Alinu Mulki,  Universitas Singaperbangsa Karawang,  Indonesia
ID Lestari Mahardika Urbaningrum ,  Universitas Singaperbangsa Karawang,  Indonesia
ID Vina Luthfiana Hasna,  Universitas Singaperbangsa Karawang,  Indonesia
ID Priscinya Christiana Debora,  Universitas Singaperbangsa Karawang,  Indonesia
DOI : https://doi.org/10.33086/ijmlst.v7i2.6538
108-120
2025-10-28
Abstract views: 724 , Downloads : 412

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Assessement of Candida albicans of the oral mucosa among type-2 diabetes mellitus patients attending Bahteramas Hospital, Southeast Sulawesi Province

ID Firdayanti Firdayanti,  Politeknik Bina Husada Kendari,  Indonesia
ID Angriani Fusvita,  Politeknik Bina Husada Kendari,  Indonesia
ID Ani Umar,  Politeknik Bina Husada Kendari,  Indonesia
DOI : https://doi.org/10.33086/ijmlst.v7i2.5496
121-129
2025-10-30
Abstract views: 443 , Downloads : 400

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In silico approach of antiviral compound from Cymbopongon citratus as the main protease SARS-CoV-2 inhibitor

ID Steven Arianto,  Institut Kesehatan Herimna,  Indonesia
DOI : https://doi.org/10.33086/ijmlst.v7i2.5754
130-137
2025-10-30
Abstract views: 429 , Downloads : 277

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STAT3, but not Ki-67, expression is independently associated with tumor progression in colorectal carcinoma: A comparative immunohistochemical biomarker analysis

ID I Gede Putu Adhi Wedharga,  Widya Mandala Surabaya Catholic University,  Indonesia
ID Vincentius Michael Willianto,  Widya Mandala Surabaya Catholic University,  Indonesia
ID Imelda Theodora,  Widya Mandala Surabaya Catholic University,  Indonesia
ID Irene Parengkuan,  Widya Mandala Surabaya Catholic University,  Indonesia
ID Bernadette Dian Novita,  Widya Mandala Surabaya Catholic University,  Indonesia
DOI : https://doi.org/10.33086/ijmlst.v7i2.7711
138-147
2025-10-31
Abstract views: 402 , Downloads : 243

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Acute oral toxicity and dose-dependent histopathological effects of Indonesian Ciplukan (Physalis angulata L.) extract in Sprague-Dawley rats

ID Thianti Sylviningrum,  Jenderal Soedirman University,  Indonesia
ID Nor Sri Inayati,  Jenderal Soedirman University,  Indonesia
ID Setiawati Setiawati,  Jenderal Soedirman University,  Indonesia
ID Fitranto Arjadi,  Jenderal Soedirman University,  Indonesia
ID Dody Novrial,  Jenderal Soedirman University,  Indonesia
DOI : https://doi.org/10.33086/ijmlst.v7i2.7921
148-159
2025-10-31
Abstract views: 616 , Downloads : 325

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