Vol. 7 No. 2 (2025): From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook

Vol. 7 No. 2 (2025) From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook

Biomedical research highlights the dual nature of natural compounds: promising therapeutic potential alongside necessary safety considerations. Studies demonstrate Bromelain and Mango seed extracts effectively combat antibiotic-resistant bacteria, while lemongrass-derived diethyl phthalate shows anti-SARS-CoV-2 activity. However, Ciplukan extract reveals organ toxicity at sublethal doses, underscoring the need for safety profiling. Concurrently, STAT3 emerges as a key independent driver in colorectal cancer progression, and environmental toxins like mosquito coil smoke are confirmed to cause emphysema. These findings collectively advocate for an integrated approach in therapeutic development, balancing efficacy with rigorous safety assessment across infectious diseases, oncology, and environmental health.

The articles in this issue were authored/co-authored by authors Malaysia and Indonesia