A Prophetic Medicine: Potential Therapeutic Effect of Nigella sativa for Osteoarthritis
DOI:
https://doi.org/10.33086/iimj.v1i2.1622Keywords:
Prophetic Medicine, Nigella sativa, OsteoarthritisAbstract
Osteoarthritis (OA) is the most common type of arthritis (inflammation of the joints). OA can affect all cartilage throughout the body, including the spine, but mainly attacks the legs from the pelvis, especially the knee to the ankle which affects about 10% of men and 18% of women over 60 years old. Pharmacotherapy, surgery, and complementary therapy are the currently managements of OA. Nigella sativa (NS) is one of the herbal plants which is part of the prophet's medicines in the Islamic world which still used. Thymoquinone (TQ) is one of NS compound, has an anti-inflammatory effect by inhibit the formation of eicosanoids in leukocytes and lipid peroxidation, or inhibit the expression of PF NF-κB subunits and p50 subunits with TNF-a promoters, and reduce levels of C-reactive protein (CRP). TQ also has a chondroprotective effects mechanism by decreases prostaglandin E2 (PGE) mediated by IL-1β and inhibits MMP synthesis in chondrocytes. Through its anti-inflammatory and chondroprotective effect, NS is a potential therapeutic agent which beneficial use for OA management without toxicological effects when given.
Downloads
References
Glyn-Jones, S. et al. Osteoarthritis. Lancet 386, 376–387 (2015).
Nelson, A. E. & Jordan, J. M. Clinical Features of Osteoarthritis. Kelley and Firestein’s Textbook of Rheumatology, 2-Volume Set (Elsevier Inc., 2017). doi:10.1016/B978-0-323-31696-5.00099-1
Health Ministry Republic of Indonesia. Hasil Utama RISKESDAS 2018. (2018).
Kooshki, A., Forouzan, R., Rakhshani, M. H. & Mohammadi, M. Effect of Topical Application of Nigella Sativa Oil and Oral Acetaminophen on Pain in Elderly with Knee Osteoarthritis: A Crossover Clinical Trial. Electron. physician 8, 3193–3197 (2016).
Mushodiq, M. A. Religionomik Hadits Al-Habbah As-Sauda’. Nizam J. Islam. Stud. 5, 119–137 (2017).
Yimer, E. M., Tuem, K. B., Karim, A., Ur-Rehman, N. & Anwar, F. Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses. Evidence-Based Complement. Altern. Med. 1–16 (2019). doi:10.1155/ 2019/1528635
Musharraf, M. & Umar, M. Prophetic Medicine is the Safest, Cheapest and Most Effective Alternative to Modern Medicine for the Treatment of Diabetes Mellitus (DM) 2: A Mini Review. Pharm. Chem. J. 5, 101–117 (2018).
Pise, H. N. & Padwal, S. L. Evaluation of anti-inflammatory activity of nigella sativa: An experimental study. Natl. J. Physiol. Pharm. Pharmacol. 7, 707–711 (2017).
Tuna, H. I., Babadag, B., Ozkaraman, A. & Balci Alparslan, G. Investigation of the effect of black cumin oil on pain in osteoarthritis geriatric individuals. Complement. Ther. Clin. Pract. 31, 290–294 (2018).
Felson, D. T. & Neogi, T. Osteoarthritis. in Harrison’s Principles of Internal Medicine 2624–2631 (McGraw-Hill Medical, 2018).
Man, G. S. & Mologhianu, G. Osteoarthritis pathogenesis - a complex process that involves the entire joint. J. Med. Life 7, 37–41 (2014).
Kolasinski, S. L. et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res. 72, 149–162 (2020).
Indonesian Rheumatology Association. Diagnosis dan Penatalaksanaan Osteoartritis. Rekomendasi IRA untuk Diagnosis dan Penatalaksanaan Osteoartritis (2014).
Hadi, V., Kheirouri, S., Alizadeh, M., Khabbazi, A. & Hosseini, H. Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. Avicenna J. phytomedicine 6, 34–43 (2016).
Arjumand, S., Shahzad, M., Shabbir, A. & Zubair, M. Biomedicine & Pharmacotherapy Thymoquinone attenuates rheumatoid arthritis by downregulating TLR2 , TLR4 , TNF- α , IL-1 , and NF κ B expression levels. Biomed. Pharmacother. J. 111, 958–963 (2019).
Turhan, Y. et al. Chondroprotective effect of Nigella sativa oil in the early stages of osteoarthritis: An experimental study in rabbits. J. Musculoskelet. Neuronal Interact. 19, 362–369 (2019).
Chen, W.-P., Tang, J.-L., Bao, J.-P. & Wu, L.-D. Thymoquinone inhibits matrix metalloproteinase expression in rabbit chondrocytes and cartilage in experimental osteoarthritis. Exp. Biol. Med. J. 235, 1425–1431 (2010).
Wang, D., Qiao, J., Zhao, X., Chen, T. & Guan, D. Thymoquinone Inhibits IL-1 β -Induced Inflammation in Human Osteoarthritis Chondrocytes by Suppressing NF- κ B and MAPKs Signaling Pathway. Inflamm. J. (2015).
Ahmad, A. et al. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac. J. Trop. Biomed. 3, 337–352 (2013).
Şeyda, M. & Ermumcu, K. Black Cumin (Nigella sativa) and its Active Component of Thymoquinone: Effects on Health. J. Food Heal. Sci. 3, 170–183 (2017).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Aufar Zimamuz Zaman Al Hajiri, Diaz Syafrie Abdillah, Mohammad Qoimam Bilqisthi Zulfikar
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
