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Ida Kurniawati Anak Agung Ayu Asri Prima Dewi Fransiscus Fiano Anthony Kerans Ni Putu Diah Witari A A I Ayesa Febrinia Adyasputri Made Agus Dwianthara Sueta Komang Trisna Sumadewi Luh Gde Evayanti Dewa Ayu Agung Alit Suka Astini

Abstract

Colorectal cancer is a leading cause of cancer-related deaths worldwide. This study


explores blood profile and cancer staging in colorectal cancer patients in Bali. It was a


descriptive-analytical study that collected demographic and clinical data from medical


records of colorectal cancer patients at Prof. Dr. I.G.N.G. Ngoerah Hospital. The results


of the study showed the basic characteristics and hematology profiles of 100 colorectal


cancer patients. The average age of patients was 55.6 ± 11.4 years, with 54% of the total


sample being male. The average body mass index (BMI) was 21.1 ± 3.6 kg/m², with an


average height of 161.9 ± 6.1 cm and an average weight of 55.3 ± 10.0 kg. Laboratory


tests revealed an average hemoglobin (Hb) level of 11.0 ± 3.6 g/dL, red blood cell count


of 4.0 ± 0.9 million/μL, white blood cell count of 11.2 ± 7.3 thousand/μL, and platelet


count of 302.8 ± 154.8 thousand/μL. The average hematocrit (HCT) level was 33.7 ±


6.6 L/L. Liver function parameters indicated average aspartate aminotransferase


(AST/SGOT) levels of 45.6 ± 63.6 U/L and alanine aminotransferase (ALT/SGPT)


levels of 24.6 ± 29.4 U/L. Renal function was described by an average blood urea


nitrogen (BUN) level of 21.8 ± 21.0 mg/dL, urea levels of 21.9 ± 21.2 mg/dL, and


creatinine levels of 2.3 ± 11.5 mg/dL. Our study highlights the importance of


hematology profiles in colorectal cancer patients as part of cancer screening


examination. Further study with a larger number of samples and more diverse


populations is needed to analyze the relation between variables.

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How to Cite
Kurniawati, I., Dewi, A. A. A. A. P., Kerans, F. F. A., Witari, N. P. D., Adyasputri, A. A. I. A. F., Sueta, M. A. D., Sumadewi, K. T. ., Evayanti, L. G. ., & Astini, D. A. A. A. S. . (2025). Hematology Profiles in Colorectal Cancer Patients in Bali. Journal of Health Sciences, 18(01), 37–43. https://doi.org/10.33086/jhs.v18i01.6936
Section
Articles
Colorectal cancer, hematology profile, laboratory examination, risk factor, pathogenesis

References

Bretthauer, M. (2011). Colorectal cancer screening. Journal of Internal Medicine, 270(2), 87–98. https://doi.org/10.1111/j.1365-2796.2011.02399.x

Demb, J., Kolb, J. M., Dounel, J., Fritz, C. D. L., Advani, S. M., Cao, Y., Coppernoll-Blach, P., Dwyer, A. J., Perea, J., Heskett, K. M., Holowatyj, A. N., Lieu, C. H., Singh, S., Spaander, M. C. W., Vuik, F. E. R., & Gupta, S. (2024). Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer. JAMA Network Open, 7(5), e2413157. https://doi.org/10.1001/jamanetworkopen.2024.13157

Elshami, M., Ayyad, M., Alser, M., Al-Slaibi, I., Ahmed Naji, S., Mohamad, B. M., Sudki Isleem, W., Shurrab, A., Yaghi, B., Qabaja, Y. A., Hmdan, F. K., Fuad Dwikat, M., Raed Sweity, R., Jneed, R. T., Assaf, K. A., Albandak, M. E., Madhat Hmaid, M., Awwad, I. I., Khalil Alhabil, B., … Bottcher, B. (2022). Awareness of colorectal cancer signs and symptoms: a national cross-sectional study from Palestine. BMC Public Health, 22(1), 866. https://doi.org/10.1186/s12889-022-13285-8

Esteva, M., Leiva, A., Ramos, M., Pita-Fernández, S., González-Luján, L., Casamitjana, M., Sánchez, M. A., Pértega-Díaz, S., Ruiz, A., Gonzalez-Santamaría, P., Martín-Rabadán, M., Costa-Alcaraz, A. M., Espí, A., Macià, F., Segura, J. M., Lafita, S., Arnal-Monreal, F., Amengual, I., Boscá-Watts, M. M., … Magallón, R. (2013). Factors related with symptom duration until diagnosis and treatment of symptomatic colorectal cancer. BMC Cancer, 13(1), 87. https://doi.org/10.1186/1471-2407-13-87

Galon, J., Mlecnik, B., Marliot, F., Ou, F.-S., Bifulco, C. B., Lugli, A., Zlobec, I., Rau, T. T., Hartmann, A., Masucci, G. V, Zavadova, E., Ohashi, P., Roehrl, M. H. A., Kawakami, Y., Torigoe, T., Ascierto, P. A., Marincola, F., Sargent, D. J., Fox, B. A., & Pages, F. (2016). Validation of the Immunoscore (IM) as a prognostic marker in stage I/II/III colon cancer: Results of a worldwide consortium-based analysis of 1,336 patients. Journal of Clinical Oncology, 34(15_suppl), 3500–3500. https://doi.org/10.1200/JCO.2016.34.15_suppl.3500

Graham, J. S., & Cassidy, J. (2012). Adjuvant therapy in colon cancer. Expert Review of Anticancer Therapy, 12(1), 99–109. https://doi.org/10.1586/era.11.189

Maida, M., Macaluso, F. S., Ianiro, G., Mangiola, F., Sinagra, E., Hold, G., Maida, C., Cammarota, G., Gasbarrini, A., & Scarpulla, G. (2017). Screening of colorectal cancer: present and future. Expert Review of Anticancer Therapy, 17(12), 1131–1146. https://doi.org/10.1080/14737140.2017.1392243

Majano, S. B., Lyratzopoulos, G., Rachet, B., de Wit, N. J., & Renzi, C. (2022). Do presenting symptoms, use of pre-diagnostic endoscopy and risk of emergency cancer diagnosis vary by comorbidity burden and type in patients with colorectal cancer? British Journal of Cancer, 126(4), 652–663. https://doi.org/10.1038/s41416-021-01603-7

Mármol, I., Sánchez-de-Diego, C., Pradilla Dieste, A., Cerrada, E., & Rodriguez Yoldi, M. (2017). Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. International Journal of Molecular Sciences, 18(1), 197. https://doi.org/10.3390/ijms18010197

Novotny, S. A., Rodrigo Amador, V. A., Seguí Orejuela, J., López-Pineda, A., Quesada, J. A., Pereira-Expósito, A., Carratalá-Munuera, C., Hernandis Villalba, J., & Gil-Guillén, V. F. (2024). Prognostic Study of Colorectal Cancer: Differences between Screen-Detected and Symptom-Diagnosed Patients. Cancers, 16(19), 3363. https://doi.org/10.3390/cancers16193363

Rex, D. K., Schoenfeld, P. S., Cohen, J., Pike, I. M., Adler, D. G., Fennerty, B. M., Lieb, J. G., Park, W. G., Rizk, M. K., Sawhney, M. S., Shaheen, N. J., Wani, S., & Weinberg, D. S. (2015). Quality Indicators for Colonoscopy. American Journal of Gastroenterology, 110(1), 72–90. https://doi.org/10.1038/ajg.2014.385

Saraste, D., Martling, A., Nilsson, P., Blom, J., Törnberg, S., & Janson, M. (2017). Screening vs. non-screening detected colorectal cancer: Differences in pre-therapeutic work up and treatment. Journal of Medical Screening, 24(2), 69–74. https://doi.org/10.1177/0969141316656216

Saratzis, A., Winter-Beatty, J., El-Sayed, C., Pande, R., & Harmston, C. (2015). Colorectal cancer screening characteristics of patients presenting with symptoms of colorectal cancer and effect on clinical outcomes. The Annals of The Royal College of Surgeons of England, 97(5), 369–374. https://doi.org/10.1308/003588415X14181254789565

Sarwono, J. (2013). Strategi Melakukan Riset, Kuantitatif, Kualitatif, Gabung. Penerbit Andi.

Schoen, R. E., Razzak, A., Yu, K. J., Berndt, S. I., Firl, K., Riley, T. L., & Pinsky, P. F. (2015). Incidence and Mortality of Colorectal Cancer in Individuals With a Family History of Colorectal Cancer. Gastroenterology, 149(6), 1438-1445.e1. https://doi.org/10.1053/j.gastro.2015.07.055

Schult, A. L., Botteri, E., Hoff, G., Randel, K. R., Dalén, E., Eskeland, S. L., Holme, Ø., & de Lange, T. (2021). Detection of cancers and advanced adenomas in asymptomatic participants in colorectal cancer screening: a cross-sectional study. BMJ Open, 11(7), e048183. https://doi.org/10.1136/bmjopen-2020-048183

Shkurti, J., van den Berg, K., van Erning, F. N., Lahaye, M. J., Beets-Tan, R. G. H., & Nederend, J. (2023). Diagnostic accuracy of CT for local staging of colon cancer: A nationwide study in the Netherlands. European Journal of Cancer, 193, 113314. https://doi.org/10.1016/j.ejca.2023.113314

Siegel, R. L., Torre, L. A., Soerjomataram, I., Hayes, R. B., Bray, F., Weber, T. K., & Jemal, A. (2019). Global patterns and trends in colorectal cancer incidence in young adults. Gut, 68(12), 2179–2185. https://doi.org/10.1136/gutjnl-2019-319511

Srivastava, S., Verma, M., & Henson, D. E. (2001). Biomarkers for early detection of colon cancer. Clinical Cancer Research, 7(5):1118-.

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660

Von Karsa, L., Patnick, J., Segnan, N., Atkin, W., Halloran, S., Lansdorp-Vogelaar, I., Malila, N., Minozzi, S., Moss, S., Quirke, P., Steele, R. J., Vieth, M., Aabakken, L., Altenhofen, L., Ancelle-Park, R., Antoljak, N., Anttila, A., Armaroli, P., Arrossi, S., … Valori, R. (2012). European guidelines for quality assurance in colorectal cancer screening and diagnosis: Overview and introduction to the full Supplement publication. Endoscopy, 45(01), 51–59. https://doi.org/10.1055/s-0032-1325997

Ida Kurniawati, Anatomy and Histology Department, Faculty of Medicine and Health Science, Warmadewa University, Indonesia

Anak Agung Ayu Asri Prima Dewi, Anatomy and Histology Department, Faculty of Medicine and Health Science, Warmadewa University, Indonesia

Fransiscus Fiano Anthony Kerans, Anatomy and Histology Department, Faculty of Medicine and Health Science, Warmadewa University, Indonesia

Ni Putu Diah Witari, Anatomy and Histology Department, Faculty of Medicine and Health Science, Warmadewa University, Indonesia

A A I Ayesa Febrinia Adyasputri, Physioterapy Department, Universitas Hindu Indonesia, Indonesia

Made Agus Dwianthara Sueta, Digestive Surgery Department/SMF, Faculty of Medicine, Udayana University, RSUP Prof. Dr. I.G.N.G. Ngoerah, Indonesia

Komang Trisna Sumadewi, natomy and Histology Department, Faculty of Medicine and Health Science, Warmadewa University, Indonesia.

Luh Gde Evayanti, Anatomy and Histology Department, Faculty of Medicine and Health Science, Warmadewa University, Indonesia.

Dewa Ayu Agung Alit Suka Astini, Anatomy and Histology Department, Faculty of Medicine and Health Science, Warmadewa University, Indonesia.