Biomarkers Of CRP, IL-6, And D-dimer Covid-19 Patients That Are Giving Convalence Plasma Therapy – Literature Review

Authors

  • Ainul Rofiq Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya
  • Reza Hery Mahendra Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya
  • Bastiana Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya
  • Yekti Tunjungsari Universitas Airlangga

DOI:

https://doi.org/10.33086/iimj.v3i1.2532

Keywords:

D-Dimer level, Interleukin 6 (IL-6) level, C-Reactive protein (CRP) level, plasma konvalesen, dan outcomes pasien COVID-19.

Abstract

Background: Convalescent plasma therapy is the only antibody-based therapy used to treat COVID-19 Patients. The use of convalescent plasma therapy has been recommended by the Food and Drug Administration (FDA) as a therapy for COVID-19 patients (FDA in Asep, 2020). Several routine biomarker parameters used as indicators in the diagnosis of COVID-19 are CRP, IL-6 and D-Dimer. There was a change between the three biomarker values of CRP, IL-6, and D-Dimer between COVID-19 patients on convalescent plasma therapy and COVID-19 patients who did not receive convalescent plasma therapy. This review article is how effective the use of convalescent plasma as therapy for COVID-19 patients is by looking at changes in the biomarkers of CRP, IL-6 and D-Dimer in patients receiving convalescent plasma therapy.

Methode: This literature review uses 3 fulltext articles obtained by combining keywords in an electronic database: Scopus, Cochrane Library, PubMed, and Google Scholar. Articles were eliminated using predefined inclusion and exclusion criteria, then analyzed systematically. The preparation of the discussion uses a systematic analysis based on the themes and topics of discussion obtained in the research article.

Conclussions: There were changes in the biomarker values of CRP, IL-6 and D-Dimer in COVID-19 patients who received convalescent plasma therapy and COVID-19 patients who did not receive convalescent plasma therapy.

Keywords: D-Dimer level, Interleukin 6 (IL-6) level, C-Reactive protein (CRP) level, plasma konvalesen, dan outcomes pasien COVID-19

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References

Elham Roshandel, Ghazaleh Sankanian, Maryam Salimi, et al. 2021. Plasma Exchange followed by convalescent plasma transfusion in COVDI-19 patients. Elsevier.

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Haithani, Apriadeny, 2021. Korelasi NEWS 2 dan Biomarker Inflamasi NLR, CRP, IL-6 Terhadap Derajat Penyakit Pasien Covid-19 di RSUP Haji Adam Malik Medan. http://repositori.usu.ac.id/handle/123, 56789/36432 Accessed on 10 Agustus 2021 13.18 WIB.

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Ling, Li., Wei, Zhang., Yu, Hu., Xunliang, Tong., Lili, Ren et al. 2021. Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life- Threatening COVID-19: A Randomized Clinical Trial. JAMA Vol. 324(5): 460-470.

Permana, Atna., Yari, Cut Ervinar., Aditya, Alaika Kurnia. 2021. Gambaran D- Dimer dan Limfosit Pada Pasien Terkonfirmasi COVID-19 di RS Haji Jakarta. Anakes: Jurnal Ilmiah Analis Kesehatan. Vol 7(1): 62-71.

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Published

2022-02-17

How to Cite

Rofiq, A., Mahendra, R. H., Bastiana, & Tunjungsari, Y. (2022). Biomarkers Of CRP, IL-6, And D-dimer Covid-19 Patients That Are Giving Convalence Plasma Therapy – Literature Review. International Islamic Medical Journal, 3(1), 51–55. https://doi.org/10.33086/iimj.v3i1.2532

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