Conservative Wound Treatment in DMT2 Patients Using Honey
Keywords:DMT2, Chronic Wound, Honey
Background : The number of diabetic patients in Indonesia is on the rise. In contrast to typical wounds in non DMT2 patients, chronic wounds in DMT2 patients heal more slowly, which makes it difficult to achieve complete primary wound healing. Thus, surgery is frequently required to achieve optimal healing. Patients' physical condition, age, comorbidities, and financial circumstances such as high medical costs frequently limiting patients from receiving comprehensive care, resulting alternative treatments are required to treat chronic wounds in DMT2 patients whom prefer conventional medications, addressing all circumstances. Honey, in addition to having fructose compounds, which has the benefit of increasing glucose homeostasis and insulin response, resulting in lower insulin and plasma glucose levels, also has been shown to contain anti-inflammatory and antimicrobial substances that aid in wound healing. Thus, it may be an alternative therapy for chronic wound in DMT2 patients.
Methods : A Case-series studies of four DMT2 patients who were referred to Plastic and Reconstructive Outpatient ward with chronic wound were evaluated on a monthly basis following conservative treatment using Nusantara local honey-coated gauze.
Result : Secondary wound healing, which can be assessed from the epithelialization process started from the peri-wound area has been obtained through monthly observations.
Conclusion : Honey is used as an alternative therapy for patients with diabetic foot ulcers due to its anti-microbial and anti-inflammatory properties in the wound healing process. Furthermore, honey is considered less expensive and more affordable alternative for patients with co-morbidities that is impossible to operate, or with financial limitations.
Keywords: DMT2, Chronic wound, Honey
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2011. 34(1):562-(9).
Molan, P.C. The Evidence Supporting the Use of Honey as a Wound Dressing. The International Journal of Lower Extremity Wounds. 2006. 5(1), 40-54.
Flahr D. The Effect of Nonweight Bearing Exercise and Protocol Adherence on Diabetic Foot Ulcer Healing a Pilot Study. Journal
Wound Management. 2010.
Kellet G. L., Brot-Laroche E., Mace
O. J. Sugar absorption in the intestine: the role of GLUT2. Annual Reviews of Nutrition. 2008;28(1):35–54. doi: 10.1146/annurev.nutr.28.061807 .155518.
Moran T. H., McHugh P. R. Distinction among three sugars in their effects on gastric emptying and satiety. American Journal of Physiology Regulatory, Integrative and Comparative Physiology. 1981;241(1):R25–R30. doi: 10.1152/ajpregu.1981.241.1.R25.
Gregory P. C., McFadyen M., Rayner D. V . Relation between gastric emptying and short-term regulation of food intake in the pig. Physiology & Bahaviour . 1989;45(4):677–683.
Thibault L. Dietary carbohydrates: effects on self-selection, plasma glucose and insulin and brain indoleaminergic systems in rat. Appetite. 1994;23(3):275–286. doi: 10.1006/appe.1994.1059
Meirelles C. J., Oliveira L. A., Jordao A. A., Navarro A. M. Metabolic effects of the ingestion of different
fructose sources in rats. Experimental and Clinical Endocrinology & Diabetes. 2011;119(4):218–220.
Molan P: Why honey is effective as a medicine. 2. The scientific explanation of its effects. Bee World 2001, 82:22-40.
Prieto P. G., Cancelas J., Villanueva- Peñacarrillo M. L., Valverde I. Plasma D-glucose, D-fructose and insulin responses after oral administration of D-glucose, D- fructose and sucrose to normal rats. Journal of the American College
of Nutrition. 2004;23(5):414–419. doi: 10.1080/07315724.2004.107193 86.
Al-Waili NS, Haq A. Effect of Honey on Antibody Production Against Thymus-Dependent and Thymus- Independent Antigens in Primary and Secondary Immune Responses. J Med Food 2004: 7(4):491-494. https://doi.org/10.1089/jmf.2004.7.4 91
Molan PC, Betts JA. Clinical Usage of Honey as a Wound Dressing: an Update. J Wound Care 2004; 13(9)353-356.
How to Cite
Copyright (c) 2023 Putu Pradnyasanti Laksmi, Made Ratna Saraswati, Ratna Rayeni Natasha Rooseno, Made Ratih Santi Devinta, Agus Santosa
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.