Severe Calciphylaxis Secondary to end Stage Renal Failure: A Case Report
Keywords:calciphylaxis, end stage renal failure
Calciphylaxis is a vascular calcification disease causing skin necrosis which contributes to high morbidity and mortality. Its exact pathogenesis is currently unknown but is commonly associated with chronic renal failure, hypercalcemia, hyperphosphatemia, secondary hyperparathyroidism and a variety of hypercoagulable state. It is relatively rare but may occur in 1-4% of patients with End Stage Renal Failure (ESRF).1 We are reporting a case of young lady with underlying ESRF presented with vascular and skin calciphylaxis.
Angelis, M., Wong, L. L., Myers, S. A., & Wong, L. M. (1997). Calciphylaxis in patients on hemodialysis: a prevalence study. Surgery, 122(6), 1083–1090. https://doi.org/10.1016/s0039-6060(97)90212-9
Fader DJ, Kang S. Calciphylaxis Without Renal Failure. Arch Dermatol. 1996;132(7):837–838. doi:10.1001/archderm.1996.03890310129026
Weenig, R. H., Sewell, L. D., Davis, M. D., McCarthy, J. T., & Pittelkow, M. R. (2007). Calciphylaxis: natural history, risk factor analysis, and outcome. Journal of the American Academy of Dermatology, 56(4), 569–579. https://doi.org/10.1016/j.jaad.2006.08.065
Baby, D., Upadhyay, M., Joseph, M. D., Asopa, S. J., Choudhury, B. K., Rajguru, J. P., & Gupta, S. (2019). Calciphylaxis and its diagnosis: A review. Journal of family medicine and primary care, 8(9), 2763–2767. https://doi.org/10.4103/jfmpc.jfmpc_588_19
Cicone, J. S., Petronis, J. B., Embert, C. D., & Spector, D. A. (2004). Successful treatment of calciphylaxis with intravenous sodium thiosulfate. American journal of kidney diseases : the official journal of the National Kidney Foundation, 43(6), 1104–1108. https://doi.org/10.1053/j.ajkd.2004.03.018
Ning, M. S., Dahir, K. M., Castellanos, E. H., & McGirt, L. Y. (2013). Sodium thiosulfate in the treatment of non-uremic calciphylaxis. The Journal of dermatology, 40(8), 649–652. https://doi.org/10.1111/1346-8138.12139
Colette B. Raymond., Lori D. W. (2008). Sodium thiosulfate, bisphosphonates, and cinacalcet for treatment of calciphylaxis, American Journal of Health-System Pharmacy, Volume 65, Issue 15, Pages 1419–1429, https://doi.org/10.2146/ajhp070546
How to Cite
Copyright (c) 2023 Muhammad Syafiq bin Mohammad Isa, Wan Ahmad Syahril Rozli Wan Ali
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.