Kinetics IgM and IgG SARS-CoV-2 in Recovery patients with Negative Evaluation RT-PCR


  • Jusup Endang General Province Hospital M. Yunus Bengkulu, Indonesia
  • Mardhatillah Sariyanti Medical and Health Sciences Faculty, Universitas Bengkulu, Indonesia
  • Dessy Triana Medical and Health Sciences Faculty, Universitas Bengkulu, Indonesia
  • Debie Rizqoh Medical and Health Sciences Faculty, Universitas Bengkulu, Indonesia
  • Nugraheni Enny Medical and Health Sciences Faculty, Universitas Bengkulu, Indonesia



Antibody, IgG, IgM, COVID-19


Background: Coronavirus is the major pathogens at human respiratory system. The antibody is a response infected patients largely not clearly. We need to understanding of antibody responses to great diagnosis and treatment studies.

Objective: In this article the objective is to describe that kinetics of IgM and IgG SARS-CoV-2 in recovery patients.

Method: Cohort study used a total 19 subjects who had negative evaluation RT-PCR after confirmed. IgG and IgM of SARS-CoV-2 were detected by IFA (Immuno fluorosence assay) used serum. Serum were collected 3 times after 1 month, 2 month and 4 month negative evaluation RT-PCR We profiled the serological responses (IgM and IgG) to SARS-CoV-2.

Result: Majority the IgM SARS-CoV-2 post evaluation RT-PCR were very low after 1,2,4 month negative evaluation. IgG SAR-CoV-2 patients post negative evaluation RT-PCR decreased after 4 months. The level IgM and IgG level increase at first week and decrease after 12 weeks.

Conclusion: IgM level lower than IgG level overtime. Quantitative IgG and IgM detection could be point of diagnosis and manifestation.


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Author Biography

Jusup Endang, General Province Hospital M. Yunus Bengkulu, Indonesia

M Yunus Goverment Hospital Bengkulu


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How to Cite

Endang, J., Sariyanti, M., Triana, D. ., Rizqoh, D., & Enny, N. (2023). Kinetics IgM and IgG SARS-CoV-2 in Recovery patients with Negative Evaluation RT-PCR. Medical and Health Science Journal, 7(02), 51–56.