Main Article Content

Jusup Endang Mardhatillah Sariyanti Dessy Triana Debie Rizqoh Nugraheni Enny

Abstract

Background: Coronavirus is the major pathogens at human respiratory system. The antibody is a response infected patients largely not clearly. We need to understanding of antibody responses to great diagnosis and treatment studies.


Objective: In this article the objective is to describe that kinetics of IgM and IgG SARS-CoV-2 in recovery patients.


Method: Cohort study used a total 19 subjects who had negative evaluation RT-PCR after confirmed. IgG and IgM of SARS-CoV-2 were detected by IFA (Immuno fluorosence assay) used serum. Serum were collected 3 times after 1 month, 2 month and 4 month negative evaluation RT-PCR We profiled the serological responses (IgM and IgG) to SARS-CoV-2.


Result: Majority the IgM SARS-CoV-2 post evaluation RT-PCR were very low after 1,2,4 month negative evaluation. IgG SAR-CoV-2 patients post negative evaluation RT-PCR decreased after 4 months. The level IgM and IgG level increase at first week and decrease after 12 weeks.


Conclusion: IgM level lower than IgG level overtime. Quantitative IgG and IgM detection could be point of diagnosis and manifestation.

Downloads

Download data is not yet available.

Article Details

How to Cite
Endang, J., Sariyanti, M., Triana, D. ., Rizqoh, D., & Enny, N. (2023). Kinetics IgM and IgG SARS-CoV-2 in Recovery patients with Negative Evaluation RT-PCR. Medical and Health Science Journal, 7(02), 51–56. https://doi.org/10.33086/mhsj.v7i02.4359
Section
Articles
Antibody, IgG, IgM, COVID-19

References

Bogoch, II, Watts A, Thomas-Bachli A, Huber C, Kraemer MUG, Khan K. Pneumonia of unknown aetiology in Wuhan, China: potential for international spread via commercial air travel. J Travel Med. 2020;27(2).

Du Toit A. Outbreak of a novel coronavirus. Nat Rev Microbiol. 2020;18(3):123.

Ren LL, Wang YM, Wu ZQ, Xiang ZC, Guo L, Xu T, et al. Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chin Med J (Engl). 2020;133(9):1015-24.

Wang W, Tang J, Wei F. Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China. J Med Virol. 2020;92(4):441-7.

Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020;109:102433.

Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. J Adv Res. 2020;24:91-8.

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395(10223):507-13.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497-506.

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.

Liu W, Fontanet A, Zhang P-H, Zhan L, Xin Z-T, Baril L, et al. Two-Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome. The Journal of Infectious Diseases. 2006;193(6):792-5.

Liu L, Wei Q, Lin Q, Fang J, Wang H, Kwok H, et al. Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. JCI Insight. 2019;4(4).

Zhao J, Yuan Q, Wang H, Liu W, Liao X, Su Y, et al. Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019. Clin Infect Dis. 2020;71(16):2027-34.

Organization WH. Coronavirus disease (COVID-19) technical guidance : Laboratory testing for 2019-nCoV in humans. World Health Organization; 2020.

Woo PC, Lau SK, Wong BH, Tsoi HW, Fung AM, Chan KH, et al. Detection of specific antibodies to severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein for serodiagnosis of SARS coronavirus pneumonia. J Clin Microbiol. 2004;42(5):2306-9.

Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-3.

Racine R, Winslow GM. IgM in microbial infections: taken for granted? Immunol Lett. 2009;125(2):79-85.

Hou H, Wang T, Zhang B, Luo Y, Mao L, Wang F, et al. Detection of IgM and IgG antibodies in patients with coronavirus disease 2019. Clin Transl Immunology. 2020;9(5):e01136.

Gozalbo-Rovira R, Gimenez E, Latorre V, Frances-Gomez C, Albert E, Buesa J, et al. SARS-CoV-2 antibodies, serum inflammatory biomarkers and clinical severity of hospitalized COVID-19 patients. J Clin Virol. 2020;131:104611.

Allegra A, Di Gioacchino M, Tonacci A, Musolino C, Gangemi S. Immunopathology of SARS-CoV-2 Infection: Immune Cells and Mediators, Prognostic Factors, and Immune-Therapeutic Implications. International Journal of Molecular Sciences. 2020;21(13):4782.

Jusup Endang, General Province Hospital M. Yunus Bengkulu, Indonesia

M Yunus Goverment Hospital Bengkulu

Mardhatillah Sariyanti, Medical and Health Sciences Faculty, Universitas Bengkulu, Indonesia

Dessy Triana, Medical and Health Sciences Faculty, Universitas Bengkulu, Indonesia

Debie Rizqoh, Medical and Health Sciences Faculty, Universitas Bengkulu, Indonesia

Nugraheni Enny, Medical and Health Sciences Faculty, Universitas Bengkulu, Indonesia