NEUROPROTECTIVE ACTIVITY OF EXTRACT OF CELERY (APIUM GRAVEOLENS) IN INSILICO STUDY
Article Sidebar
Main Article Content
Abstract
Backround: Celery (Apium graveolens L., Apiaceae) is one of the medicinal plants with secondary metabolite components that have pharmacological effects such as vitamin (choline) content. This study aims to evaluate the mechanism and interaction of choline contained in celery on its effectiveness as a neuroprotective.
Methods: This research is an experimental research using the in silico study.
Results: The insilico search found that the choline content in celery binds to Slc5a7, Chat and Ache. Which has a function in the process of neurotransmitter biosynthesis, neurotransmitter metabolic processes and neurotransmitter secretion processes
Conclusion: The celery (Apium graveolens L., Apiaceae) have pharmacological activity as neuroprotective through the interaction of Slc5a7, Chat and Ache
Downloads
Article Details
Copyright (c) 2021 Reza Mahendra, Ainul Rofik, Hotimah Masdan Salim, Maria Ulfa, Evy Silvia Awwaliyah
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
References
Khairullah, A. R. et al. Review on the pharmacological and health aspects of apium graveolens or celery: An update. Syst. Rev. Pharm. 12, 606–612 (2021).
Solikhah, T. I., Setiawan, B. & Ismukada, D. R. Antidiabetic activity of papaya leaf extract (Carica Papaya L.) isolated with maceration method in alloxan-induces diabetic mice. Syst. Rev. Pharm. 11, 774–778 (2020).
Kooti, W. & Daraei, N. A Review of the Antioxidant Activity of Celery ( Apium graveolens L). J. Evid. Based. Complementary Altern. Med. 22, 1029–1034 (2017).
Jittiwat, J., Chonpathompikunlert, P. & Sukketsiri, W. Neuroprotective effects of Apium graveolens against focal cerebral ischemia occur partly via antioxidant, anti-inflammatory, and anti-apoptotic pathways. J. Sci. Food Agric. 101, 2256–2263 (2021).
Al-Howiriny, T. et al. Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats. Pharm. Biol. 48, 786–793 (2010).
Sameh, B., Ibtissem, B., Mahmoud, A., Boukef, K. & Boughattas, N. A. Antioxidant Activity of Apium graveolens Extracts. J. Biol. Act. Prod. from Nat. 1, 340–343 (2011).
Brahma Srinivasa Rao Desu and Sivaramakrishna K. Anti-Depressant Activity of Methanolic Extract of Apium Graveolens Seeds. Int. J. Res. Pharm. Chem. 2, 1124–1127 (2012).
Baananou, S. et al. Antiulcerogenic and antibacterial activities of Apium graveolens essential oil and extract. Nat. Prod. Res. 27, 1075–1083 (2013).
Liu, D. K. et al. Evaluation of bioactive components and antioxidant capacity of four celery (Apium graveolens L.) leaves and petioles. Int. J. Food Prop. 23, 1097–1109 (2020).
Choudhary, P. et al. Discovery of Compounds that Positively Modulate the High Affinity Choline Transporter. Front. Mol. Neurosci. 10, 40 (2017).
Wang, H. et al. Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization. Brain 140, 2838–2850 (2017).
Tönnies, E. & Trushina, E. Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease. J. Alzheimers. Dis. 57, 1105–1121 (2017).
Obermayer, J., Verhoog, M. B., Luchicchi, A. & Mansvelder, H. D. Cholinergic Modulation of Cortical Microcircuits Is Layer-Specific: Evidence from Rodent, Monkey and Human Brain. Front. Neural Circuits 11, 100 (2017).