Buah Mengkudu (Morinda citrifolia) Meningkatkan Respon Imun Mencit (Mus musculus) Terhadap Infeksi Bakteri Staphylococcus aureus


  • Mufidah Zumrotul




Mengkudu, Staphylococcus, aureus, limfosit, CD4 , T


Noni (Morinda citrifolia) Increase Immune Response in Mice (Mus musculus) Infected Staphylococcus aureusInfection disease caused by bacteria is one of the illness in several developing countries including in Indonesia, with high mortality rate. Infection of  S. aureus as the cause of problem resistance for antibiotic or multi drug resistance are giving the therapy of drug itself with change to medical herbal. The aim of this study is known the role of M.citrifoliaextract to increase immune response of mice with infectioned of S. aureus. Mice were divided into two groups there are Non Infection and infection. Non Infection is without S. aureus and than infection has S. aureus. The each groups are including control, dose 1 (25 mg/kg BW), dose 2 (100 mg/kg BW), and dose 3 (300 mg/kg BW). Relative number of lymphocyte T cell (CD4+) subsets was measured  using the BD FACSCaliburTM Flowcytometer. Data were analyzed using Analysis of Varians (p<0,05) and using SPSS 16 for windows. The result showed that administration of  M. citrifolia crude extract in non infection groups was significantly increase the relative amounts T cell subsets (CD4+). Noni fruit extract can used as prevention therapy on infection disease of S. aureus bacteria because it contains active compounds that are anti-inflammationMengkudu


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Maranani, Z.Z. 2010. Influence Of Health Care Toward Staphylococcus aureus Infection and Antimicrobial Resistance In Patient Of dr. Kariadi Hospital Semarang Period 200892009. Thesis. Semarang: Universitas Diponegoro.
Franzeska, A.D. 2010. Influence Of Demographic Factor Toward Staphylococcus aureus Infection and Antimocrobial Resistance Patiens Of dr. Kariadi Hospital Semarang 2008-2009. Thesis. Semarang: Universitas Diponegoro
Susanti R & Margareta R. 2003. Aktivitas Fagositosis Neutrofil Terhadap Staphylococcus aureus Isolat Sapi di Jawa Tengah dengan Teknik Acridine Orange Fluorescence. Berk. Penel. Hayati: Hal.61-66
Jawetz, E. 2005. Mikrobiologi Kedokteran. Jakarta: EGC.
Kumar, P., Sukhla I., Varshney S. 2011. Nasal screening of Healthcare workers for nasal carriage of coagulase positive MRSA and Prevalence of nasal Colonization with Staphylococcus aureus. Biology and Medicine. 3 (2): 182-186.
Depkes. 2003. Imunisasi untuk anak dan Dewasa. HTA Indonesia: 1-22.
Abbas AK, Lichman, AH. 2005. Basic Immnology: Function and Dissorder of The Imun System. China: Elsevier. Pp 134-349.
Rifa’i M. 2011. Autoimun dan Bioregulator. Malang: UB Press. Hal 29-164.
Nayak S, Sushma M. 2009. Immunostimulant activity of the extracts and bioactives of the fruits of Morinda citrifolia. Pharmaceutical Biology 47 (3): 248–254.
Soraya, A.I., Peramiarti dan Busono B. 2011. Efektivitas Kombinasi Ekstrak Buah Mengkudu (Morinda citrifolia) dan Selenium Sulfida Terhadap Penghambatan Pertumbuhan Koloni Pityrosporum ovale. Mandala of Health. 5 (2):195
Nandhasri, P., Sopit T., Tadsanee P., Somboon K. 2011. Bio9extract Concentrated of Thai çYoré Morinda citrifolia Effects in Analgesic, Acute Toxicity and Human Peripheral Blood Mononuclear Cells. Thammasat Medical Journal. 11 (1):8-17
Li, J., S.L. Stickel., H.B. Verville., K.E. Burgin., X.Yu., D.K.W. Wong., T.E. Wagner dan Y. Wei. 2008. Fermented Noni Exudate (fNE): A mediator between immune system and anti-tumor activity. Oncology Reports 20: 1505-1509.
Teixeira, F.M., B. F. Fernandes, A. B. Rezende, R. R. P. Machado, C. C. S. Alves, S. M. Perobelli, S. I. Nunes, R. E. Farias, M. F. Rodrigues, A. P. Ferreira, S. C. Oliveira and H. C. Teixeira. 2008. Staphylococcus aureus infection after splenectomy and splenic autotransplantation in BALB/c mice. Clinical and Experimental Immunology. 154: 255–263
Fraser, J. D., & T. Proft. 2008. The bacterial superantigen and superantigen like proteins. Immunol. Rev. 225: 226–243.
Krakaeuer, T. 2011. Comparative Potency of Green Tea and Red Wine Polyphenols in Attenuating Staphylococcal Superantigen Induced Immune Responses. American Journal Biomedical Sciences. 4 (2): 1579166.
Mufidah, Z., M. Rifa’i., S. Rahayu. 2013. Immunomodulators activity of Noni (Morinda citrifolia) fruit extract in mice infected with Staphylococcus aureus. Jurnal Veteriner. 11 (4): 501-510
Mahattanadul, S., Ridtitid., W. Nima S., Phdoongsombut N., Ratanasuwon P., Kasiwong S. 2010. Effects of Morinda citrifolia aqueous fruit extract and its biomarker scopoletin on reflux esophagitis and gastric ulcer in rats. Journal of Ethnopharmacology. 134:243-250.
Deng S., Palu, A.K., West, B.J., Su, C.X., Zhou, B.N., Jensen, J.C., 2007. Lipoxygenase inhibitory constituents of the fruits of Noni (Morinda citrifolia) collected in Tahiti. Journal of Natural Products. 70: 859–862.
Ikeda, R., Wada, M., Nishigaki, T., Nakashima, K., 2009. Quantification of coumarin derivatives in Noni (Morinda citrifolia) and their contribution of quenching effect on reactive oxygen species. Food Chemistry.113: 1169–1172.
Moon, P.D., Lee, B.H., Jeong, H.J., An, H.J., Park, S.J., Kim, H.R., Ko, S.G., Um, J.Y., Hong, S.H., Kim,H.M., 2007.Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the IB/NF9B signal cascade in the human mast cell line HMC91. European Journal of Pharmacology. 555: 218–225.
Rastini EK, Aris WM, Saifur RM. 2010. Pengaruh Pemberian Ekstrak Buah Mengkudu (Morinda citrifolia L.) Terhadap Aktivasi NF-ĸβ dan Ekspresi Protein (TNF-α, ICAM-1) pada Kultur Sel Endotel (HUVECs) Dipapar Ox-LDL. J Exp Life Sci 1 (1):48-55




How to Cite

Zumrotul, M. (2015). Buah Mengkudu (Morinda citrifolia) Meningkatkan Respon Imun Mencit (Mus musculus) Terhadap Infeksi Bakteri Staphylococcus aureus. Journal of Health Sciences, 6(2). https://doi.org/10.33086/jhs.v6i2.34