the influence of giving katu’s leaf extract fraction toward prolactin level of breastfeeding mice and neuralgia cells of young mice

Nurul Kamariyah

doi:10.33086/jhs.v5i2.14

Authors

Nurul Kamariyah

DOI:

https://doi.org/10.33086/jhs.v5i2.14

Keywords:

Prolactin, Neuralgia cell, Sauropus Androgynus, (L.). Merr (Katu), Mice

Abstract

People knew that Sauropus androgynus (L) Merr (katu’s leaf) have good nutrient and can enhance breast milk production. Study about influence of giving katu’s leaf extract fraction toward prolactin level and neuralgia cells in mice is not available recently. The purpose of this study is to find out the influence of giving katu’s leaf extract fraction toward prolactin level and neuralgia cells at mice, and influence prolactin level in breast feeding mouse towards amount of neuralgia cells in mice. Method of this study is laboratories experiment ”the post test-only control group” type experimental animals is mouse (Rattus norvegicus). The samples are 24 breast feeding mice with body weight 150-200 gram and divided into 4 groups, that are control group and treatment group which is given katu’s leaf extract fraction. Treatment group 1 with the dosage 24 mg, treatment group 2 with the dosage 48 mg and treatment group 3 with the dosage 72 mg. Treatment begun at the 3^rd day post delivery until the 11^th day. The 12^th day the mouse is killed, blood from pericardium taken for prolactin test, while the mice is killed and it’s brain made as substance for testing of amount of neuralgia cells. Study result of prolactin with One Way Anova got significant difference (ρ=0,000). Continued with Post Hoc test got significant difference at C–T2, C–T3, T1–T2, T1–T3, and T2–T3. Result of neuralgia cells test at One Way Anova got significant difference (p=0,000). Continued with Post Hoc test got significant difference at C–T2, C–T3, T1–T2, T1–T3, and T2–T3. Result of linier regression test got ρ (0.940) > α (0,05), means there is no influence prolactin level in breast feeding mouse towards amount of neuralgia cells in mice. The conclusion of the study was prolactin level in breast feeding mouse and amount of neuralgia cells in mice after giving katu’s leaf extract fraction have prolactin level higher and amount of neuralgia cells increase at the dosage 48 and 72 mg. If this study will be applied to human, should be done laboratorial test. More study about containing of breast milk after giving katu’s leaf extract fraction need to be continued.

Downloads

Download data is not yet available.

References

Byrnes E M, Bridges R S (2005): Lactation reduces prolaktin levels in reproductively ekperienced female rats, hormones and behavior. http://www.scienedirect.com/sdience?ObarticleURL&ufdiB6WGC4G3KCO7-8&-user. Diakses tanggal 2 Januari 2011
Chatterton R T, Hill P D (2000): Relation of plasma oxytocin and prolaktin consentration to milk production in mother of preterm infants: Influence of Stress; J.C.E.M. http://jcem.endojournal.org/cgi/content/full/85/10/3661. Diakses 25 Desember2010
Departemen Kesehatan RI (2000). Parameter standart umum ekstrak tumbuhan obat. Cetakan pertama. Direktorat Jendral Pengawasan Obat dan Makanan. Jakarta.
Fang H, dkk (2001), Structure-activity relationship for alarge diverse set of naturall, synthetic, and environmental estrogens. Chem Res Toxicol
Farida, (2010), Hubungan antara perawatan payudara dengan produksi air susu ibu di kelurahan Wonokromo Surabaya. Laporan penelitian mahasiswa STIKES RSI Surabaya.
Hamilton WJ (1976). Female reproductive organs. In Textbook of Human Anatomy, 2nd edition. The Mac Millan Press Ltd., London
Jay N. Giedd. (1999). Brain development during childhoodand adolescence: a longitudinal MRI study. http://neurobci.nature.com. Natural America Inc.
Lita Feriyawati, (2005) Anatomi system saraf dan peranannya dalam regulasi kontraksi otot rangka. USU. Repository.
Lisa, (2009) Hubungan antara status gizi dengan kecerdasan anak. http:ayurai.wordpress.com/2009/04/22hubungan-antara-status-gizi-dengan-kecerdasan-anak/ diakses tanggal 29 Oktober 2011
Mangestuti, A. (1997). Isolasi zat kandungan aktif daun sauropus androgynus (L.) Merr. Yang berkhasiat laktagogum. Disertasi. Program pasca sarjana Universitas Airlangga Surabaya.
Martina D.N. (2007). Isolasi kandungan senyawa daun Sauropuis laktagogum daun Sauropus Androgynus (L.) Merr. Skripsi: Fakultas Farmasi Universitas Airlangga. Surabaya
Nikmatus, 2010, Hubungan antara pemberian ASI ekslusif dengan berat badan anak dikelurahan Wonokromo Surabaya. Laporan penelitian karya tulis ilmiah mahasiswa STIKES RSI Surabaya.
Nugraheni, Noor. W. Uji 2009. Uji toksitas akut ekstrak valerian (valeriana officinalis) terhadap otak tikus Balb/c. (jurnal) staf pengajar bagian farmakologi Fakultas Kedokteran Universitas Diponegoro.
Reza A, (2007). Isolasi kandungan senyawa daun Sauropus Androgynus (L) Merr. Skripsi: Fakultas Farmasi Universitas Airlangga. Surabaya
Santoso, U., T. Suteky, Heryanto, Sunarti. (2002b). Pengaruh cara pemberian ekstrak daun katu (Sauropus androgynus) terhadap penampilan dan kualitas karkas ayam pedaging.
Sri, H. W. (2004). Isolasi dan identifikasi asam fenolat pada daun katu (Sauropus Androgynus (L). Merr. Skripsi: Jurusan Farmai. FMIPA. Institut Sains dan Tehnologi Nasional. Jakarta
Saparinah Sadli (2005): Kesehatan Reproduksi perempuan dan hak asasi manusia: dalam bunga rampai obstetri dan ginekologi sosial, YBP-SP.
Subekti, S. (2003). Kualitas telur dan karkas ayam lokal yang diberi tepung daun katu dalam ransum. PPS IPB, Bogor.
Suprayogi, A. (2000). Studies on the biological effect of Sauropus androgynus (L) Merr.: Effects on milk production and the possibilities of induced pulmonary disorder in lactating sheep. George-August, Universitat Gottingen Institut fur Tierphysiologie und Tierernahrung.
Yahya, (2010). Air susu ibu dan kecerdasan anak. http:ayurai.wordpress.com/2009/04/22hubungan=antara-status-gizi-dengan-kecerdasan-anak/diakses tanggal 29 Oktober 2011
Zulhaida, (2006). Status ibu hamil serta pengaruhnya terhadap bayi yang dilahirkan. PT Gramedia. Jakarta