Anti-Hypertensive Drugs and Sexual Dysfunction in Men
DOI:
https://doi.org/10.33086/jhs.v13i01.1335Keywords:
obat anti hipertensi, pria, disfungsi seksualAbstract
Salah satu faktor yang memiliki risiko yang terkait dengan kejadian disfungsi seksual pada pria adalah obat anti-hipertensi. Obat anti-hipertensi yang memiliki efek menyebabkan disfungsi seksual pada pria termasuk; diuretik, Clonidine, dan β-blocker (kecuali nebivolol), tetapi ada beberapa obat anti-hipertensi yang memiliki efek netral, bahkan memiliki efek positif yang dalam hal ini dapat meningkatkan fungsi seksual pada pria. Obat anti-hipertensi yang memiliki efek netral pada fungsi seksual pria meliputi; Calcium Channel Blocker dan ACE-Inhibitor dan yang memiliki efek meningkatkan fungsi seksual pada pria termasuk; ARB dan β-blocker yaitu nebivolol. Penggunaan obat anti-hipertensi dapat mempengaruhi fungsi seksual pada pria melalui mekanisme yang berbeda. Obat anti-hipertensi seperti diuretik, β-blocker, dan clonidine dapat menyebabkan disfungsi seksual pada pria melalui mekanisme perubahan dalam aliran simpatis, efek pada kontraksi otot polos fisik, dan melalui pengaruh pada kadar hormon androgen. Angiotensin Receptor Blocker dan Nebivolol dapat meningkatkan fungsi seksual melalui mekanisme penghambatan pada Angiotensin II dan meningkatkan bioavailabilitas Nitric Oxide.
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References
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2. Garko B. Sexual Dysfunction in Hypertensive Patients:Implications For Therapy. Ann Afr Med. 2005; 2(4):46-51.
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6. Manolis A, Doumas M. Antihypertensive Treatment and Sexual Dysfunction. Curr Hypertens Rep.2012;14:285-92.
7. Dusing R. Sexual Dysfunction in Male Patients with Hypertension:Influence of Antihypertensive Drugs. Drugs.2005;65 (6):773-86.
8. Spatz ES.Sexual Activity and Function among Middle-Aged and Older Men and Women with Hypertension. J Hypertens.2013;31(6):1-11.
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10. Guay AT, Spark RF, Bansal S, et al.AACE Guidelines for Clinical Practice for the Evaluation and Treatment of Male Sexual Dysfunction: A Couple’s Problem-2003 Update.Endocr Pract. 2003; 1(9):78-95.
11. Yang L, Yu J, Ma R, Lin X, et al.The Effect of Combined Antihypertensive Treatment (Felodipine with Either Irbesartan or Metoprolol) on Erectile Function: A Randomized Controlled Trial.Cardiol J.2013;125:235-41.
12. Schiffrin EL.Circulatory Therapeutics:Use of Antihypertensive Agents and Their Effects on The Vasculature. J Cell Mol Med.2010;5(14):1018-29.
13. Doumas M, Tsakiris A, Douma S et al.Beneficial Effect of Switching from β-Blockers to Nebivolol on the Erectile Function of Hypertensive Patients. Asian J Androl.2006;8(2):177-82.
14. Ekman E, Haag S, Sundstrom S, et al.Antihypertensive Drugs and Erectile Dysfunction as seen in Spontaneous Reports, With Focus on Angiotensin II Type I Receptor Blockers. Drug Healthc Patient Saf. 2010; 2: 21-5.
15. Kloner RA, Sadovsky R, Johnson EG, et al.Efficacy of Tadalafil in the Treatment of Erectile Dysfunction in Hypertensive Men on Concomitant Thiazide Diuretic Therapy. Int J Impot Res.2005;17:450-4.
16. Manolis AJ, Doumas M, Viigima M.Hypertension and Sexual Dysfunction. European Society of Hypertension Scientific Newsletter:Update on Hypertension Management.2007;32(8):1-11.
17. Conaglen HM, Conaglen JV.Drug-Induced Sexual Dysfunction in Men and Women. Aust Prescr.2013;36:42-5.
18. Dean RC, lue TF. Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction. Urol Clin North Am.2005;32(4):379-385.
19. Rastogi S, Rodriquez JJ, Kapur V, et al.Why do Patients With Heart Failure Suffer From Erectile Dysfunction? A Critical Review and Suggestions on how To Approach this Problem. Int J Impot Res.2005;17:25-36.
20. Smith S.Drugs that cause Sexual Dysfunction. Psychiatry.2007;6(3):111-114.
21. Vlachopoulos C, Jackson G, Stefanadis C et al. Erectile Dysfunction in the Cardiovascular Patient. Eur Heart J. 2013;34:2034-46.
22. Ryu JK, Cho KS, Kam SC et al. Korean Society for Sexual Medicine and Andrology (KSSMA) Guideline on Erectile Dysfunction.World J Mens Health.2013;31(2):83-102.
23. La Torre A, Glupponi G, Duffy D et al.Sexual Dysfunction Related To Drugs: A Critical Review. Pharmacopsychiatry.2015;48:1-6.
24. Ozawa Y, Hayashi K, Kobori H. New Generation Calcium Channel Blockers in Hypertensive Treatment. Curr Hypertens Rev.2006;2(2):103-11.
25. Walker R, Sonia R. ACE POEMs (Patient Oriented Evidance that Matters). Bpacnz POEM 15: ACE Inhibitors.2006;8:1-22.
26. Van Zwieten PA. Centrally Acting Antihypertensive: A Renaissance of Interest. Mechanism and Haemodynamics. J Hypertens.1997; 15: 3-8.
27. Nunes KP, Labazi H, Webb RC .New Insight into Hypertension-Associated Erectile Dysfunction.Curr Opin Nephrol Hypertens.2012; 21(2):163-170.
28. Wang D, Wang W, Liu AJ et al.Long-Term Treatment of Clonidinee, Atenolol, Amlodipine and Dihydrochlorothiazide, but Not Enalapril, Impairs the Sexual Function in Male Spontaneously Hypertensive Rats. Plos One.2015;3:1-13.
29. Martinez-Portillo FJ.Priapism, Pathophysiology And Management. International Braz J Urol.2003;5(29):391-400.
30. Nunes KP, Webb RC. Mechanism in Erectile Function and Dysfunction: An Overview, Erectile Dysfunction – Disease Associated Mechanisms and Novel Insights into Therapy. In Techopen.2012;3:1-21.
31. Ferrario CM, Levy P.Sexual Dysfunction in Patients With Hypertension: Implication for Therapy.J Clin Hypertens.2002;6(4):424-432.
32. J Kaminetsky.Epidemiology and Pathophysiology of Male Sexual Dysfunction.Int J Impot Res. 2008; 20:3-10.
33. Salman M, Shehzadi N, Khan MT et al. Erectile Dysfunction: prevalence, risk factors and involvement of antihypertensive drugs intervention.Trop J Pharm Res.2016;15 (4):869-76.
34. Reffelmann T, Kloner R.Sexual Function in Hypertensive Patients Receiving Treatment.Vasc Health Risk Manag.2006;2(4):447-55.
35. Eardley I. Pathophysiology Of Erectile Dysfunction. Br J Diabetes Vasc Dis. 2002;4(2): 272-76.
36. Isidori A M, Giannetta E, Gianfrilli D et al.Effect of Testosterone on Sexual Function in Men: Results Of a Meta Analysis. J Clin Endocrinol Metab. 2005; 63:381-94.
37. Traish A M, Galoosian A.Androgens Modulate Endothelial Function and Endothelial Progenitor Cells in Erectile Physiology.Korean J Urol.2013; 54:721-31.
38. Raifer J.Relationship Between Testosterone and Erectile Dysfunction. Rev Urol.2000;2(2):122-8.
39. Antwerp J.Neurogenic Sexual Dysfunction. 2nd Int Neuro-Urology Meeting. 2013;2:1-4.
40. Fode M, Brackett NL, Ohl DA et al. Male Sexual Dysfunction And Fertility Associated With Neurological Disorders. Asian J Androl.2012; 14:61-8.
41. Booth AM. Physiology of Male Sexual Function. Ann Intern Med.1980;92: 329-331.
42. Miller WL.The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and its Disorders. Endocr Rev.2011;32(1):81-151.
43. Weiss R. Nebivolol:a novel beta-blocker with nitric oxide-induced vasodilatation.Vasc Health Risk Manag. 2006;2(3):303-8.
44. Dorrance AM, Lewis RW, Mills TM. Captoril treatment reverse erectile dysfunction in male stroke Prone Spontaneously Hypertensive Rats. Int J Impot Res. 2002;14:494-7.
45. Doumas M et al.Beneficial Effects of switching from β-blockers to nebivolol on the erectile function of hypertensive patients.Asian J Androl.2006;8(2):177-182.
46. Basile JN. The Role of Vasodilating β-blockers in controlling Hypertension as a means of Reducing Cardiovacular and Stroke Risk. American J Med.2010;7(123):S9-S15.
47. Fraga Silva RA, Montecucco F, Mach F et al. Pathophysiology Role of the Renin-Angiotensin System on Erectile Dysfunction. Eur J Clin Invest.2013;7:1-9.
48. Maffei A, Lembo G.Nitric Oxide mechanisms of Nebivolol.Ther Adv Cardiovasc Dis.2009;3(4):317-327.
2. Garko B. Sexual Dysfunction in Hypertensive Patients:Implications For Therapy. Ann Afr Med. 2005; 2(4):46-51.
3. Hatzimouratidis K, Eardley I, Giuliano F, et al. Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and Premature Ejaculation. EAU. 2015:p2-10.
4. Kandeel FR, Koussa KT, Swerdloff.Male Sexual Function and Its Disorders: Physiology, Pathophysiology, Clinical Investigation, and Treatment. Endocr Rev. 2001; 22(3): 342-88.
5. Chiesa AD, Ptiffner D, Meier B, et al.Sexual Activity in Hypertensive Men. J Hum Hypertens.2003;17: 515-21.
6. Manolis A, Doumas M. Antihypertensive Treatment and Sexual Dysfunction. Curr Hypertens Rep.2012;14:285-92.
7. Dusing R. Sexual Dysfunction in Male Patients with Hypertension:Influence of Antihypertensive Drugs. Drugs.2005;65 (6):773-86.
8. Spatz ES.Sexual Activity and Function among Middle-Aged and Older Men and Women with Hypertension. J Hypertens.2013;31(6):1-11.
9. Javaroni V, Neves MF. Erectile Dysfunction and Hypertension:Impact on Cardiovascular Risk and Treatment. Int J Hypertens. 2012:p; 1-11.
10. Guay AT, Spark RF, Bansal S, et al.AACE Guidelines for Clinical Practice for the Evaluation and Treatment of Male Sexual Dysfunction: A Couple’s Problem-2003 Update.Endocr Pract. 2003; 1(9):78-95.
11. Yang L, Yu J, Ma R, Lin X, et al.The Effect of Combined Antihypertensive Treatment (Felodipine with Either Irbesartan or Metoprolol) on Erectile Function: A Randomized Controlled Trial.Cardiol J.2013;125:235-41.
12. Schiffrin EL.Circulatory Therapeutics:Use of Antihypertensive Agents and Their Effects on The Vasculature. J Cell Mol Med.2010;5(14):1018-29.
13. Doumas M, Tsakiris A, Douma S et al.Beneficial Effect of Switching from β-Blockers to Nebivolol on the Erectile Function of Hypertensive Patients. Asian J Androl.2006;8(2):177-82.
14. Ekman E, Haag S, Sundstrom S, et al.Antihypertensive Drugs and Erectile Dysfunction as seen in Spontaneous Reports, With Focus on Angiotensin II Type I Receptor Blockers. Drug Healthc Patient Saf. 2010; 2: 21-5.
15. Kloner RA, Sadovsky R, Johnson EG, et al.Efficacy of Tadalafil in the Treatment of Erectile Dysfunction in Hypertensive Men on Concomitant Thiazide Diuretic Therapy. Int J Impot Res.2005;17:450-4.
16. Manolis AJ, Doumas M, Viigima M.Hypertension and Sexual Dysfunction. European Society of Hypertension Scientific Newsletter:Update on Hypertension Management.2007;32(8):1-11.
17. Conaglen HM, Conaglen JV.Drug-Induced Sexual Dysfunction in Men and Women. Aust Prescr.2013;36:42-5.
18. Dean RC, lue TF. Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction. Urol Clin North Am.2005;32(4):379-385.
19. Rastogi S, Rodriquez JJ, Kapur V, et al.Why do Patients With Heart Failure Suffer From Erectile Dysfunction? A Critical Review and Suggestions on how To Approach this Problem. Int J Impot Res.2005;17:25-36.
20. Smith S.Drugs that cause Sexual Dysfunction. Psychiatry.2007;6(3):111-114.
21. Vlachopoulos C, Jackson G, Stefanadis C et al. Erectile Dysfunction in the Cardiovascular Patient. Eur Heart J. 2013;34:2034-46.
22. Ryu JK, Cho KS, Kam SC et al. Korean Society for Sexual Medicine and Andrology (KSSMA) Guideline on Erectile Dysfunction.World J Mens Health.2013;31(2):83-102.
23. La Torre A, Glupponi G, Duffy D et al.Sexual Dysfunction Related To Drugs: A Critical Review. Pharmacopsychiatry.2015;48:1-6.
24. Ozawa Y, Hayashi K, Kobori H. New Generation Calcium Channel Blockers in Hypertensive Treatment. Curr Hypertens Rev.2006;2(2):103-11.
25. Walker R, Sonia R. ACE POEMs (Patient Oriented Evidance that Matters). Bpacnz POEM 15: ACE Inhibitors.2006;8:1-22.
26. Van Zwieten PA. Centrally Acting Antihypertensive: A Renaissance of Interest. Mechanism and Haemodynamics. J Hypertens.1997; 15: 3-8.
27. Nunes KP, Labazi H, Webb RC .New Insight into Hypertension-Associated Erectile Dysfunction.Curr Opin Nephrol Hypertens.2012; 21(2):163-170.
28. Wang D, Wang W, Liu AJ et al.Long-Term Treatment of Clonidinee, Atenolol, Amlodipine and Dihydrochlorothiazide, but Not Enalapril, Impairs the Sexual Function in Male Spontaneously Hypertensive Rats. Plos One.2015;3:1-13.
29. Martinez-Portillo FJ.Priapism, Pathophysiology And Management. International Braz J Urol.2003;5(29):391-400.
30. Nunes KP, Webb RC. Mechanism in Erectile Function and Dysfunction: An Overview, Erectile Dysfunction – Disease Associated Mechanisms and Novel Insights into Therapy. In Techopen.2012;3:1-21.
31. Ferrario CM, Levy P.Sexual Dysfunction in Patients With Hypertension: Implication for Therapy.J Clin Hypertens.2002;6(4):424-432.
32. J Kaminetsky.Epidemiology and Pathophysiology of Male Sexual Dysfunction.Int J Impot Res. 2008; 20:3-10.
33. Salman M, Shehzadi N, Khan MT et al. Erectile Dysfunction: prevalence, risk factors and involvement of antihypertensive drugs intervention.Trop J Pharm Res.2016;15 (4):869-76.
34. Reffelmann T, Kloner R.Sexual Function in Hypertensive Patients Receiving Treatment.Vasc Health Risk Manag.2006;2(4):447-55.
35. Eardley I. Pathophysiology Of Erectile Dysfunction. Br J Diabetes Vasc Dis. 2002;4(2): 272-76.
36. Isidori A M, Giannetta E, Gianfrilli D et al.Effect of Testosterone on Sexual Function in Men: Results Of a Meta Analysis. J Clin Endocrinol Metab. 2005; 63:381-94.
37. Traish A M, Galoosian A.Androgens Modulate Endothelial Function and Endothelial Progenitor Cells in Erectile Physiology.Korean J Urol.2013; 54:721-31.
38. Raifer J.Relationship Between Testosterone and Erectile Dysfunction. Rev Urol.2000;2(2):122-8.
39. Antwerp J.Neurogenic Sexual Dysfunction. 2nd Int Neuro-Urology Meeting. 2013;2:1-4.
40. Fode M, Brackett NL, Ohl DA et al. Male Sexual Dysfunction And Fertility Associated With Neurological Disorders. Asian J Androl.2012; 14:61-8.
41. Booth AM. Physiology of Male Sexual Function. Ann Intern Med.1980;92: 329-331.
42. Miller WL.The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and its Disorders. Endocr Rev.2011;32(1):81-151.
43. Weiss R. Nebivolol:a novel beta-blocker with nitric oxide-induced vasodilatation.Vasc Health Risk Manag. 2006;2(3):303-8.
44. Dorrance AM, Lewis RW, Mills TM. Captoril treatment reverse erectile dysfunction in male stroke Prone Spontaneously Hypertensive Rats. Int J Impot Res. 2002;14:494-7.
45. Doumas M et al.Beneficial Effects of switching from β-blockers to nebivolol on the erectile function of hypertensive patients.Asian J Androl.2006;8(2):177-182.
46. Basile JN. The Role of Vasodilating β-blockers in controlling Hypertension as a means of Reducing Cardiovacular and Stroke Risk. American J Med.2010;7(123):S9-S15.
47. Fraga Silva RA, Montecucco F, Mach F et al. Pathophysiology Role of the Renin-Angiotensin System on Erectile Dysfunction. Eur J Clin Invest.2013;7:1-9.
48. Maffei A, Lembo G.Nitric Oxide mechanisms of Nebivolol.Ther Adv Cardiovasc Dis.2009;3(4):317-327.
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2020-02-05
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Tarukallo, N., & Rasyid, H. . (2020). Anti-Hypertensive Drugs and Sexual Dysfunction in Men. Journal of Health Sciences, 13(01), 1–11. https://doi.org/10.33086/jhs.v13i01.1335
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