Role Of Moringa Oleifera Leaf Extract In Increasing Hemoglobin Levels In Pregnant Rats With Anemia

Role Of Moringa Oleifera Leaf Extract In Increasing Hemoglobin Levels In Pregnant Rats With Anemia

Authors

  • Reny Retnaningsih Poltekkes RS dr Soepraoen Kesdam V
  • Rani Safitri Universitas Nahdlatul Ulama Surabaya

DOI:

https://doi.org/10.33086/jhs.v14i1.1296

Keywords:

Daun Kelor (Moringa oleifera), Kadar Hemoglobin, Anemia

Abstract

Anemia is one of the epidemic health problems in society and the most common nutritional problem. The Moringa oleifera is rich in excellent dietary content and can complement the body's needs. This study aims to determine Moringa oilefera leaf extract's effectiveness in increasing hemoglobin levels in pregnant rats (Ratus norvegicus) with anemia. This paper used a true experimental research design with a pre-post test randomized control group design. This study utilized female rats (Ratus norvegicus), pregnant 8-12 weeks, weighing 200 grams. Experimental procedures were four treatments with three repetitions. Types of treatment were negative control and positive control (administration of Moringa oilefera leaf extract) at a dose of 0.18 g / head, 0.36 g / head, and 0.72 g/head. Analysis using one way ANOVA with an error rate of 0.05. The results showed p<0.005, which means a significant increase in hemoglobin levels in the group given the treatment of moringa leaf extract at a dose of 0.72 g/head/day. The conclusion and suggestion from this research are public could get information about using natural materials as economically valuable drugs (back to nature)

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References

Aaronson, Philip, Ward, Jeremy P.T. (2008) At a Glance. Sistem Kardiovaskuler. Edisi Ketiga. Jakarta: Erlangga.

Ahmad, Alnur Aulia. (2015) Pengaruh Pemberian Seduhan Daun Kelor (Moringa oleifera Lam) Terhadap Jumlah Leukosit Tikus Putih (Ratus norvegicus) Jantan. Program Studi Ilmu Gizi. Universitas Diponegoro.

Coulibaly, A., Gnangoran, B. N., Oussou, J. B. N. G., & Bleyere, M. N. (2020) 'Evaluation of Moringa oleifera Lam leaves (Moringaceae) diets against induced anemia in Wistar rats', J. Nutr. Food Sci, 2(3), 101-106.

Dahlan, Sopiyudin. (2013) Statistik Untuk Kedokteran dan Kesehatan. Deskriptif, Bivariat dan Multivariat. Dilengkapi Aplikasi Dengan Menggunakan SPSS. Salemba Medika. Jakarta.

Departemen Kesehatan R.I. (2013) Program Penanggulangan Anemia Gizi pada Wanita Usia Subur (WUS); (Safe Motherhood Project: A Partnership and Family Approach). Direktorat Gizi Masyarakat. Jakarta: Direktorat Jenderal Bina Kesehatan Masyarakat Depkes.

Duthie, G., Duthie, S., and Kyle, J. (2000) 'Plant Polyphenols in Cancer as Nutritional Antioxidants', Nutritional Research Reviews. 76 – 106.

Fahey, J.W., (2005) 'Moringa Oleifera: A Review of the Medical Evidence for Its

Nutritional, Therapeutic and Prophylatic Properties'. Trees for Life Journal,

(5), pp.82 - 87.

Gibney, M.J., Margetts, B.M., Kearney, J.M., Arab, L. (2008) Gizi Kesehatan Masyarakat. Public Health Nutrition. Jakarta: EGC.

Gopalakrishnan, L., Doriya, K., & Kumar, D. S. (2016), 'Moringa oleifera: A review on nutritive importance and its medicinal application'. Food science and human wellness, 5(2), 49-56.

Ibok, O.W., O Elilis, and Deborah, O. (2008) 'Nutritional potential of two leafy vegetables moringa oleifera and ipomoea batas leaves'. Scientific research and Essyvol 3 (2) pp. 057-060.

Kusriningrum, R.S. (2008) Perancangan Percobaan. Airlangga University Press. Surabaya.

Luthfiyah, F. (2012) Efek Serbuk Daun Kelor (Moringa Oleifera) Lokal Nusa Tenggara Barat (NTB) Dalam Meningkatkan Performance Profil Darah Lengkap Tikus Model Kurang Energi Protein. Jurnal Kesehatan Prima. Vol 6(1)

Madukwe E.U., Ugwuoke A.L., Ezeugwu J.O. (2013) 'Effectiveness of dry Moringa oleifera leaf powder in the treatment of anemia' International Journal of Medicine and Medical Sciences. Vol 5 (5). Pp 226-228

Nieman, D. C. et al. (2007) 'Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA', Journal of Applied Physiology, 103(5), pp. 1728–1735. doi: 10.1152/japplphysiol.00707.2007.

Rajanandh, M., Satishkumar, M., Elango, K, and Suresh, B. (2012) Moringa oleifera Lam. A herbal Medicine for Hyperlipidemia: A Pro-Clinical Report. Departement of Pharmacology, J.S.S University. India.

Saralaya MG, Patel P, Patel M, Roy SP, Patel AN. (2010) 'Antidiarrheal activity of methanolic extract of Moringa oleifera lam roots in experimental animal models', Int J Pharmaceutic Res;2:35-9

Shija, A. E., Rumisha, S. F., Oriyo, N. M., Kilima, S. P., & Massaga, J. J. (2019). 'Effect of Moringa Oleifera leaf powder supplementation on reducing anemia in children below two years in Kisarawe District, Tanzania', Food science & nutrition, 7(8), 2584-2594.

Sindhu, S., Mangala, S., & Sherry, B. (2013). 'Efficacy of Moringa oleifera in treating iron deficiency anemia in women of reproductive age group', International Journal of Physiotherapy Research, 3(4), 15-20.

Sitohang, P. C., Candriasih, P., & Amdani, S. (2018). 'Effect of Moringa (Moringa oleifera) biscuit administration on kemoglobin levels of pregnant women', International Journal of Sciences: Basic and Applied Research, 37, 243-252.

Sherwood, L. (2011) Fisiologi Manusia. Dari Sel Ke Sistem. Edisi 6. Jakarta: EGC

Udupa, SL, Udupa, AL & Kulkarni, DR 1994, 'Studies on the anti-inflammatory and wound healing properties of Moringa oleifera and Aegle marmelos', Fitoterapia, vol. 65, no. 2, pp. 119-123.

Youssry, M. A., Radwan, A. M., Gebreel, M. A., & Patel, T. A. (2018). 'Prevalence of maternal anemia in pregnancy: the effect of maternal hemoglobin level on pregnancy and neonatal outcome', Open Journal of Obstetrics and Gynecology, 8(7), 676-687.

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Published

2021-02-26

How to Cite

Retnaningsih, R., & Safitri, R. . (2021). Role Of Moringa Oleifera Leaf Extract In Increasing Hemoglobin Levels In Pregnant Rats With Anemia : Role Of Moringa Oleifera Leaf Extract In Increasing Hemoglobin Levels In Pregnant Rats With Anemia . Journal of Health Sciences, 14(1), 8–13. https://doi.org/10.33086/jhs.v14i1.1296