The Effect of Vitamin-D Supplementation on HDAC2 Levels in Stable COPD Patients
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Adyan Donastin
Danny Irawan
Effendy
Rifky Dwi Aditya Iryawan
Nuzlan Nuari
Betta Mega Oktaviana
Devy Yahya
Akbar Reza Muhammad
Abstract
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of global
mortality, with persistent lung inflammation contributing to its progression. This
inflammation is partially due to reduced levels of the Histone deacetylase 2 (HDAC2)
protein. Research shows that Vitamin D can modulate HDAC2 levels and slow the
advancement of COPD. This experimental study aimed to evaluate the effect of vitamin
D supplementation on HDAC2 expression in stable COPD patients at Jemursari Islamic
Hospital. Five randomly selected COPD patients received a daily dosage of 5000 IU of
Vitamin D for three months. Serum levels of 25(OH) D and HDAC2 were measured
before and after the intervention. The results showed a significant increase in both
Vitamin D and HDAC2 levels, with a notable, though not statistically significant,
improvement in lung function. The findings suggest that consistent Vitamin D
supplementation can reduce inflammation by raising HDAC2 levels, potentially slowing
lung damage in COPD patients. Therefore, Vitamin D treatment is beneficial in
managing COPD by improving lung health and preventing disease progression.
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Copyright (c) 2026 Adyan Donastin, Danny Irawan, Effendy, Rifky Dwi Aditya Iryawan, Nuzlan Nuari, Betta Mega Oktaviana, Devy Yahya, Akbar Reza Muhammad
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