The Relationship of HbA1c Levels and Degree of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus in RSI Jemursari Surabaya
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Putri Dhiya Ayu Shofiyah
Lea Maera Shanty
Marselli Widya Lestari
Abstract
Introduction: Type 2 diabetes mellitus is a metabolic disorder frequently associated with long-term complications. One of the most common microvascular complications is diabetic nephropathy, a condition that significantly contributes to morbidity and mortality among patients. A reduced glomerular filtration rate (GFR) reflects a more advanced stage of nephropathy, and when accompanied by elevated HbA1c levels, it indicates poor glycemic control and a greater risk of diabetes-related complications.
Objective: To prove the relationship between HbA1c levels and the degree of diabetic nephropathy
Methods: This study is an analytical observational research with a cross-sectional approach. The population in this study consists of medical record data from patients with type 2 diabetes mellitus at RSI Jemursari, totaling 946 patients. The sample was obtained using the Slovin formula, with a 10% margin of error, resulting in 90 samples. Sampling was done using the nonprobability sampling method of consecutive sampling. The statistical test uses the Spearman test in SPSS.
Results: The significance value was <0.001 (<0.1), and the correlation coefficient was 0.416. The results of the Spearman statistical test demonstrate a significant relationship between the two variables, with a moderate quality of the relationship between them.
Conclusions: A significant relationship was found between the HbA1c level variable and the degree of nephropathy in patients with type 2 diabetes mellitus, characterized by a correlation coefficient indicating a moderate quality of relationship.
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Copyright (c) 2026 Putri Dhiya Ayu Shofiyah, Lea Maera Shanty, Marselli Widya Lestari
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References
Banday, M. Z., Sameer, A. S., & Nissar, S. (2020). Pathophysiology of diabetes: An overview. Avicenna Journal of Medicine, 10(04). https://doi.org/10.4103/ajm.ajm_53_20
Francisco, P. M. S. B., Assumpção, D. de, Bacurau, A. G. de M., Silva, D. S. M. da, Yassuda, M. S., & Borim, F. S. A. (2022). Diabetes mellitus in older adults, prevalence and incidence: results of the FIBRA study. Revista Brasileira de Geriatria e Gerontologia, 25(5). https://doi.org/10.1590/1981-22562022025.210203.en
Gounden, V., Bhatt, H., & Jialal, I. (2024, July 27). Renal Function Tests. National Library of Medicine.
Kautzky-Willer, A., Leutner, M., & Harreiter, J. (2023). Sex differences in type 2 diabetes. In Diabetologia (Vol. 66, Issue 6). https://doi.org/10.1007/s00125-023-05891-x
Kusdiyah, E., Makmur, M. J., & Aras, R. B. P. (2021). Karakteristik Faktor - Faktor Terjadinya Komplikasi Kronik Nefropati Diabetik dan atau Penyakit Pembuluh Darah Perifer pada Penderita Diabetes Mellitus di RSUD Raden Mattaher Tahun 2018. Electronic Journal of Scientific Environmental Health And Disease, 1(1). https://doi.org/10.22437/esehad.v1i1.10761
Levey, A. S., Titan, S. M., Powe, N. R., Coresh, J., & Inker, L. A. (2020). Kidney disease, race, and GFR estimation. Clinical Journal of the American Society of Nephrology, 15(8). https://doi.org/10.2215/CJN.12791019
Majid, F., Uwan, W. B., & Zakiah, M. (2020). Hubungan kadar HbA1c terhadap laju filtrasi glomerulus dan proteinuria pada penderita diabetes melitus tipe 2. Journal Cerebellum, 5(4A). https://doi.org/10.26418/jc.v6i1.43346
Soelistijo, S. (2021). Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia 2021. In the Global Initiative for Asthma.
Tarawifa, S., Bonar, S. B., & Sitepu, I. (2020). Hubungan Kadar HbA1c dengan Resiko Nefropati Diabetikum pada Pasien DM Tipe 2 di RSUD H. Abdul Manap Kota Jambi. Jurnal Ilmu Kedokteran Dan Kesehatan, 7(2). https://doi.org/10.33024/jikk.v7i2.2755
Wahyuningsih, S., Nugroho, H., Suhartono, S., Hadisaputro, S., & Adi, M. S. (2019). Faktor Risiko Kejadian Nefropati Diabetika pada Wanita. Jurnal Epidemiologi Kesehatan Komunitas, 4(1). https://doi.org/10.14710/jekk.v4i1.4426